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Table 3 Unadjusted and adjusted models assessing the association of HIV co-infection with plasma MCP-1 levels (log10 pg/mL) in ATAHC

From: HIV infection is associated with higher levels of monocyte chemoattractant protein-1 and eotaxin among people with recent hepatitis C virus infection

 

Unadjusted model

Adjusted modela

Estimated mean differenceb (95 % CI)

P

Estimated mean differenceb (95 % CI)

P

HIV co-infection

    

 Negative

Reference

 

Reference

 

 Positive

0.13 (0.06, 0.19)

<0.001

0.11 (0.03, 0.18)

0.009

Age, 10 years

0.04 (0.00, 0.07)

0.024

0.01 (−0.03, 0.05)

0.575

Symptomatic acute HCV

    

 No

Reference

   

 Yes

0.06 (−0.01, 0.13)

0.080

  

ALT level, log IU/L

0.07 (0.00, 0.14)

0.049

0.02 (−0.05, 0.10)

0.502

Estimated duration of infection

    

  <26 weeks

Reference

   

  ≥26 weeks

−0.05 (−0.12, 0.02)

0.196

  

Interferon lambda rs12979860 genotype

    

 TT/CT

Reference

   

 CC

0.01 (−0.06, 0.08)

0.809

  

HCV RNA level

    

  <400,000 IU/mL

Reference

 

Reference

 

  ≥400,000 IU/mL

0.05 (−0.02, 0.12)

0.181

0.02 (−0.06, 0.10)

0.623

HCV genotypec

    

 Genotype 1

Reference

   

 Genotype 3

0.00 (−0.07, 0.08)

0.937

  

 Other

0.09 (−0.05, 0.23)

0.222

  
  1. aAdjusted for variables associated with MCP-1 levels in unadjusted analysis or HIV status (i.e. age, ALT levels, and HCV RNA levels) as well as assay run (n = 117, R 2 = 0.14)
  2. bβ coefficient
  3. cOverall P = 0.467