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Table 1 Demographic and clinical characteristics of patients hospitalized at Intensive Care Unit

From: Hospital-acquired infections at an oncological intensive care cancer unit: differences between solid and hematological cancer patients

Characteristic – n (%)

Total (N = 157)

Solid tumor (n = 104)

Hematological malignancies (n = 53)

P-value

Gender – Masculine

80 (51)

43 (41.3)

37 (69.8)

<0.001

Age (years)a

48 ± 15

50.5 ± 15.5

43.9 ± 15.7

0.009

Comorbiditiesb

   

0.257

Arterial hypertension

Diabetes mellitus

Smoking

Obesity

HIV

Other

31 (19.7)

29 (18.5)

19 (12.1)

19 (12.1)

2 (1.3)

13 (8.3)

23 (22.1)

23 (22.1)

13 (12.5)

15 (15.4)

1 (1)

8 (7.7)

8 (15.1)

6 (11.3)

6 (11.3)

4 (7.5)

3 (5.7)

5 (9.4)

Type of tumorc

   

−

NHL

HL

Acute leukemia

Myeloma multiple

Myelodysplastic

Germ cell tumors

Gastrointestinal

Cervical

Breast

Skin and soft tissue

Ovarian

Head and neck

Other tumors

22 (14)

2 (1.3)

22 (14)

4 (2.5)

4 (2.5)

12 (7.6)

23 (14.6)

10 (6.4)

10 (6.4)

10 (6.4)

8 (5.1)

7 (4.5)

20 (12.7)

-

-

-

-

12 (11.5)

23 (22.1)

10 (9.6)

10 (9.6)

10 (9.6)

8 (7.7)

7 (6.7)

20 (19.2)

22 (41.5)d

2 (3.8)

22 (41.5)

4 (7.5)

4 (7.5)

-

-

-

-

-

-

Stagee

    

I-II

III-IV

38 (36.2)

67 (63.8)

33 (86.8)

5 (13.2)

50 (74.6)

17 (25.4)

0.211

Oncologic status

   

0.03

Recent diagnosis

Progression

Relapse

Complete remission

96 (61.1)

30 (19.1)

19 (12.1)

12 (7.6)

57 (54.8)

21 (20.2)

14 (13.5)

12 (11.5)

39 (73.6)

9 (17)

5 (9.4)

0

Chemotherapy in the last 30 daysf

48 (30.6)

19 (18.3)

29 (54.7)

<0.001

Radiotherapy in the last 6 months

11 (7)

3 (2.9)

8 (15.1)

0.007

Neutropeniag

9 (5.7)

4 (3.8)

5 (9.4)

0.02

Pancytopenia

20 (12.7)

1 (1)

19 (35.8)

<0.001

Hospitalization in the last 90 days

45 (28.7)

21 (20.2)

24 (45.3)

0.001

ICU admission

   

<0.001

Respiratory failure

Septic shock

Hypovolemic shock

Postsurgical

Post-CPR

Other causesh

54 (34.4)

34 (21.7)

29 (18.5)

13 (8.3)

7 (4.4)

20 (12.7)

25 (24)

20 (19.2)

28 (26.9)

13 (12.6)

6 (5.8)

12 (11.5)

29 (54.7)

14 (26.4)

1 (1.9)

0

1 (1.9)

8 (15.1)

Days from hospitalization to ICU admissioni

2 (1,8)

0 (1,7)

4 (1,13)

0.02

APACHE-II scoreaj

18.9 ± 6.4

18.4 ± 6.7

19.9 ± 5.6

0.134

SOFA scoreak

8.6 ± 3.6

8.4 ± 3.9

9.2 ± 3.1

0.197

  1. aMean ± standard deviation
  2. b HIV human immunodeficiency virus; other comorbidities: 4 patients with thyroid dysfunction. 1 with chronic kidney failure, 2 with chronic liver failure, 1 with Down syndrome, 1 with ischemic heart disease, 3 with neurologic disease and1 with rheumatologic disease
  3. c NHL non-Hodgkin lymphoma; HL = Hodgkin lymphoma; other tumors: lung, bladder, kidney, peripheral nerve, brain
  4. dOne patient who received hematopoietic stem cell transplantation
  5. eStage was documented in 105 patients: 38 solid and 67 hematologic, percentage was calculated with these numbers. The rest of the patients were not stratified because had a neoplasia unclassifiable
  6. fOne patient received sorafenib for kidney cancer and one receive bortezomib for multiple myeloma. Three patients received radiotherapy with concomitant chemotherapy
  7. gFour patients had anemia plus neutropenia, and five had neutropenia plus thrombocytopenia
  8. hKidney failure, cerebrovascular accident, water-electrolyte imbalance, metabolic acidosis and neurologic impairment
  9. iMedian (interquartile range)
  10. jAcute Physiology and Chronic Health Evaluation
  11. kSequential Organ Failure Assessment
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BMC Infectious Diseases

ISSN: 1471-2334

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