Table 3 Economic burden of CDI in non-community (hospital, LTC, LTAC) and community settings in $USD. Figures in parentheses are percentage of total costs

Cost of Primary CDI Cases ($USD)

Cost of Recurrent CDI ($USD)

Total Cost, Primary and Recurrent ($USD)

Direct Costs Due to CDI

3,077,422,555(65.14 %)

1,515,321,696(32.07 %)

4,592,744,251(97.21 %)

Hospitalization Costs of Initial Cases

2,448,638,121(51.83 %)

1,228,876,113(26.01 %)

3,677,514,233(77.84 %)

Pharmacotherapy Costs of CDI Cases

182,348,058(3.86 %)

111,155,318(2.35 %)

293,503,376(6.21 %)

Healthcare Professional Costs of Initial Cases

271,079,343(5.74 %)

112,255,374(2.38 %)

383,334,717(8.11 %)

Surgical and Medical Procedure Costs

175,357,033(3.71 %)

63,034,891(1.33 %)

238,391,925(5.05 %)

Indirect Costs Due to CDI

Productivity Costs

92,848,421(1.97 %)

39,010,416(0.83 %)

131,858,837(2.79 %)

Cumulative number of hospital days

1,475,896(0.03 %)

801,821(0.02 %)

2,277,718(0.05 %)

Number of Lost Productivity Days

800,309(0.02 %)

348,256(0.01 %)

1,148,565(0.02 %)

Total Non-Community Cost

3,170,270,976(67.10 %)

1,554,332,112(32.90 %)

4,724,603,089(100.00 %)

Cost or Days of Primary CDI($USD or days)

Cost or Days of Recurrent CDI($USD or days)

Total, Primary and Recurrent($USD or days)

Direct Costs Due to CDI

577,985,724(79.78 %)

69,767,755(9.63 %)

647,753,479(89.41 %)

Hospitalization Costs of Initial Cases

337,526,181(46.59 %)

43,205,334(5.96 %)

380,731,515(52.55 %)

Pharmacotherapy Costs of CDI Cases

92,088,119(12.71 %)

13,914,636(1.92 %)

106,002,754(14.63 %)

Healthcare Professional Costs of Initial cases

58,520,790(8.08 %)

5,214,073(0.72 %)

63,734,863(8.80 %)

Surgical and Medical Procedure Costs

89,850,635(12.40 %)

7,433,712(1.03 %)

97,284,347(13.43 %)

Indirect Costs Due to CDI

Productivity Costs

69,351,125(9.57 %)

7,393,919(1.02 %)

76,745,044(10.59 %)

Cumulative Number of Hospital Days

197,951(0.03 %)

26,213(0.00 %)

224,163(0.03 %)

Number of Lost Productivity Days

602,020(0.08 %)

68,108(0.01 %)

670,128(0.09 %)

Total Community Cost

647,336,849(89.35 %)

77,161,674(10.65 %)

724,498,524(100.00 %)

Cost or Days of Primary CDI($USD or days)

Cost or Days of Recurrent CDI($USD or days)

Total, Primary and Recurrent($USD or days)

Direct Costs Due to CDI

3,655,408,279(67.08 %)

1,585,089,451(29.09 %)

5,240,497,731(96.17 %)

Hospitalization Costs of Initial Cases

2,786,164,301(51.13 %)

1,272,081,447(23.34 %)

4,058,245,748(74.48 %)

Pharmacotherapy Costs of CDI Cases

274,436,177(5.04 %)

125,069,954(2.30 %)

399,506,131(7.33 %)

Healthcare Professional Costs of Initial cases

329,600,133(6.05 %)

117,469,447(2.16 %)

447,069,580(8.20 %)

Surgical and Medical Procedure Costs

265,207,668(4.87 %)

70,468,604(1.29 %)

335,676,272(6.16 %)

Indirect Costs Due to CDI

Productivity Costs

162,199,547(2.98 %)

46,404,335(0.85 %)

208,603,882(3.83 %)

Cumulative Number of Hospital Days

1,673,847(0.03 %)

828,034(0.02 %)

2,501,881(0.05 %)

Number of Lost Productivity Days

1,402,329(0.03 %)

416,364(0.01 %)

1,818,693(0.03 %)

Total Cost

3,817,607,826(70.06 %)

1,631,493,786(29.94 %)

5,449,101,612(100.00 %)