Changing distribution of age, clinical severity, and genotypes of rotavirus gastroenteritis in hospitalized children after the introduction of vaccination: a single center study in Seoul between 2011 and 2014

Table 1 Clinical characteristics of 179 children with rotavirus infection including age, vaccination status and clinical severity

Clinical Parameters	Total	<3 month	3–23 months	24–59 months	≥60 months	P value^*
Clinical Parameters	(n = 179)	(n = 12)	(n = 59)	(n = 73)	(n = 35)	P value^*
Ages, months	30 [17.0–50.0]	0.85 [0.6–2.0]	16.5 [12.0–21.5]	37.5 [29.3–45.00]	80.5 [71.5–100.5]
Vaccination status, n (%)
complete	19 (10.6)	0	10	9	0	0.09
rotateq	14	0	10	4	0	0.007
rotarix	5	0	0	5	0	0.179
incomplete	6	4	1	1	0
Modified Vesikari score	12 [11–13]	9 [8.25–12]	12 [11–13]	12 [11–13]	12 [10–13]	0.565
≥11, n (%)	135 (75.4)	4 (33.3)	47 (79.7)	58 (79.5)	26 (74.3)	0.777
Vomiting duration, h, n (%)						0.007
0	21 (11.7)	7	8	5	1
1–24	137 (76.5)	4	50	57	26
25–48	17 (9.5)	1	0	9	7
≥49	4 (2.2)	0	1	2	1
Maximum number of episodes per 24-h, n (%)						0.036
0	21 (11.7)	7	8	5	1
1	21 (12.1)	1	7	9	4
2–4	81 (45.3)	3	30	33	15
≥5	56 (31.3)	1	14	26	15
Diarrhea duration, h, n (%)
0	24 (13.4)	1	4	15	4	0.042
1–96	148 (82.7)	11	51	55	31
97–120	3 (1.7)	0	2	1	0
≥121	4 (2.2)	0	2	2	0
Maximum number of episodes per 24-h, n (%),						0.021
0	24 (13.4)	1	4	15	4
1–3	57 (31.8)	4	16	22	15
4–5	39 (21.8)	4	15	12	8
≥6	59 (33.0)	3	24	24	8
Fever, °C, n (%)						0.791
≤37.0	21 (11.7)	3	4	10	4
37.1–38.4	76 (42.5)	6	27	28	15
38.5–38.9	49 (27.4)	1	18	20	10
≥39.0	33 (18.4)	2	10	15	6
Visit to ER, n (%)	105 (58.7)	7	34	49	15	0.838
Seizure, n (%)	6 (3.4)	1	2	3	0	0.614
Total CO2, mmol/L	17 [15.0–19.0]	20.5 [17.0–23.5]	16 [14.0–18.0]	17 [15.0–9.0]	18 [16.0–21.0]	0.031

ISSN: 1471-2334