Author, study location (ref) | Study year | Population | Age | Number | Follow-up period (timing of follow-up visits) | Mean or median follow-up | Anatomical site | Outcomes (definition used for any/HR-HPV)c |
---|---|---|---|---|---|---|---|---|
Tobian, Uganda [19] | 2003–2007 | HIV + ve/-ve men | 15–49 | 999 | 2 years (6, 12, 24 m) | Mean 14.4 m | Penile | Inc (TS, total) Clr (TS) |
Kjaer, Denmark [63] | 2000–2003 | Military servicemen | 18–19 | 374 | 6 m (6 m) | Range 5.4–7.8 m | Penile | Inc (NTS) |
Backes, Kenya [17] | 2002–2005 | Uncircumcised men | 17–24 | 966 | 1 year (6, 12 m) | Median 12.1 m | Penile | Inc (NTS, first) |
Mbulawa, South Africa [22] | Not reported | HIV + ve/-ve men | 19–67 | 486 | 2 years (6, 12, 18, 24 m) | - | Penile | Inc (TS, first) Clr (TS)a |
Videla, Spain [23] | 2005–2009 | HIV + ve men | 20- > 69 | 733 | 5 years (annual) | Median 24 m | Penile, anal, oral | Inc (NTS, first) Clr (NTS) |
Wikström A, Sweden [21] | Not reported | MSW, sexually active without clinical HPV | 18–54 | 235 | (1–5 visits) | Mean 3.5 m between visits | Penile | Inc (TS) Clr/Pers (TS) |
Gray, Uganda [18] | 2003–2006 | HIV-ve married men | 15–49 | 840 | 24 m (6, 12, 24 m) | - | Penile | Inc Clr |
Serwadda, Uganda [16] | 2003–2007 | HIV + ve men | 15–49 | 210 | 24 m (24 m) | - | Penile | Inc (TS) Clr |
Grabowski, Uganda [24] | 2003–2007 | HIV + ve/-ve men | 15–49 | 936 | 24 m (6, 12, 24 m) | - | Penile | Pers (TS) |
Giuliano, Brazil, Mexico, USA [53] | 2005–2009 | HIV-ve men | 18–70 | 1159 | 4 years (every 6 m) | Median 27.5 m | Penile | Inc (NTS, first) Clr (TS) |
Darwich, Spain [20] | 2005–2009 | HIV + ve men | 20- > 69 | 606 | 5 years (annual) | Median 24 m | Penile, anal | Incb Clr |
de Pokomandy, Canada [38] | 2002–2007 | HIV + ve MSM | 21–66 | 247 | 3 years (every 6 m) | Mean 30.8 m | Anal | Inc Clr |
Nyitray, Brazil, Mexico, USA [35] | 2005–2009 | Men | 18–70 | MSM:156 MSW:954 | 6 m (6 m) | Median 6.7 m | Anal | Inc (TS) Clr (TS) Pers (TS) |
Goodman, Hawaii, USA [36] | 1998–2003 | Sexually active women | 18–85 | 431 | 5 years (every 4 m) | Mean 16 m | Anal | Inc (NTS, first) Clr (TS) |
Shvetsov, Hawaii [39] | 1998–2003 | Sexually active women | 18–85 | 431 | 5 years (every 4 m) | Mean 16 m | Anal | Clr (TS) |
Moscicki, USA [40] | 1990- > 2004 | Sexually active women | 13–21 | 75 | 3–9.5 years (every 4 m) | Mean 84.5 m | Anal | Clr (TS, 2+ neg) |
Mullins, USA [37] | 1996–2001 | HIV + ve and HIV-ve at risk | 12–18 | 496 | 6 years (annual) | Mean 22.4 m | Anal | Inc (NTS, first) |
Glick, USA [33] | 2009–2010 | MSM | 16–30 | 94 | 1 year (every 6 m) | - | Anal | Inc (NTS, unclear) Clr (TS) |
Hernandez, USA [34] | 1998–2000 | HIV + ve MSM | Mean 45 | 369 | 2 years (every 6 m) | - | Anal | Inc (TS, total) |
Lu, Arizona USA [31] | 2003–2005 | Men | 18–44 | 285 | 2 years (every 6 m) | Median 15.5 m | Male genital (shaft, coronal sulcus, glans, scrotum) | Inc (TS, total) Clr (TS) |
Hernandez, Hawaii [59] | 2004–2006 | Circ, UnC men | 18–79 | 357 | 2.5 years (every 2 m) | Mean 14 m | Male genital (coronal sulcus, glans, shaft, scrotum) | Clr (TS, 2+ neg) |
Giuliano, Arizona USA [25] | 2003–2005 | Men | 18–44 | 290 | 2 years (every 6 m) | Mean 15.5 m | Male genital (coronal sulcus, glans, shaft, scrotum) | Inc (NTS, first & total) Pers (NTS) Clr (NTS) |
Morales, Mexico [26] | 2003–2004 | MSW | Median 36 | 351 | 3 years (every 4 m) | Median 19.8 m | Male genital (scrotum, shaft, balano-preputial groove, urinary meatus) | Inc (NTS, unclear) Clr (TS) |
Partridge, USA [29] | 2003–2006 | MSW university students | 18–20 | 240 | 3 years (every 4 m) | Median 12.9 m | Male genital (glans &urethral meatus, shaft, scrotum) | Inc (NTS, first) |
Lajous, Mexio [27] | 2000–2003 | Male soldiers | 16–40 | 336 | 1 year (1 year) | - | Male genital (shaft, coronal sulcus, scrotum urethral meatus) | Inc (NTS) Clr (TS) Pers (TS) |
Albero, Brazil, Mexico, USA [28] | 2005–2009 | HIV-ve men | 18–70 | 4033 | 4 years (every 6 m) | Median 17.5 m | Male genital (shaft, coronal sulcus, glans, scrotum) | Inc (NTS, first) Clr (TS, 2+ neg) |
Winer, USA [43] | 1990–2000 | Female university students | 18–20 | 444 | 10 year (every 4 m) | Mean 41.2 m | Vulvovaginal | Inc (NTS, first) |
Edelstein, USA [45] | 2008–2010 | Male university students | Median 20 | 212 | 1.5 years (every 4 m) | Median 10.7 m | Oral (rinse/OP swab) | Inc (NTS, first) |
Kero, Finland [48] | Not reported | Male partners of pregnant women | 19–46 | 131 | 7 years (2, 6, 12, 24, 36 m & 7 years) | Mean at visit 1: 1.8 m, visit 2: 5.9 m, visit 3: 12.1 m, visit 4: 24.7 m, visit 5: 36.8 m, visit 6: 77.0 m | Oral (scraping) | Inc |
Kero, Finland [30] | 2006–2008 | Pregnant women and their male partners | Women: 19–46 Men: 20–52 | 46 women, 46 men | 7 years (7 years) | - | Oral (scraping), male genital (penis/urethra) | Inc (NTS) Clr (TS) |
Kero, Finland [46] | Not reported | Males partners of pregnant women | 20–52 | 129 men | 7 years (2, 6, 12, 24, 36, 7 years) | Mean in 74 HPV + ve 43.8 m | Oral (scraping) | Inc (NTS, first) Clr (TS) |
Louvanto, Finland [51] | Not reported | Women with persistent cervical HPV (≥24 months) and HPV-ve controls | Mean 25.2–26.4 | 43 cases 52 controls | 6 years (possibly annual) | Mean 65.2 m (cases) 38.4 m (controls) | Oral (scraping) | Clr(TS) |
Rintala, Finland [50] | 2006–2008 | Pregnant women and their male partners | Women: 19–46 Men: 20–52 | 331 women, 131 men | 2 years (2, 6, 12, 24 m) | Mean 26.9 m (women) 25.9 m (men) | Oral (scraping) | Inc (NTS, first) Clr (NTS) |
Pickard, USA [49] | 2009–2010 | University students | 18–30 | 1000 | 3 m (3 m) | - | Oral (rinse) | Inc (TS) Clr (TS) Pers (TS) |
D’Souza, USA [15] | 2004–2005 | HIV + ve and high-risk HIV-ve adult women | Not reported | 199 | 6 m (6 m) | - | Oral (rinse) | Inc (TS) Clr (NTS) |
Kurose, Japan [52] | 2000–2002 | Healthy volunteers | 3–85 | 662 | 2.5 years (2.5 years) | - | Oral (scraping) | Clr (TS) Pers (TS) |
Darwich, Spain [47] | 2005–2009 | HIV + ve men | Median 41 | 733 | 5 years (annual) | Median 24 m | Oral (scraping/rinse) | Clr (TS) |
Kreimer, Brazil, Mexico, USA [44] | 2007–2009 | HIV-ve men | 18–70 | 1626 | 4 years (every 6 m) | Median 12.7 m | Oral (rinse) | Inc (NTS, first) Clr (TS) |