| Unmatched data set (n = 345) | Unmatched data set (IPTW, n = 345) | Matched data set (n = 254) | |||
---|---|---|---|---|---|---|
Independent variable | OR (95Â % CI) | P-value | OR (95Â % CI) | P-value | OR (95Â % CI) | P-value |
Inappropriate empirical antibiotic therapy | 1.26 (0.64–2.48) | 0.499 | 1.33 (0.83–2.12) | 0.236 | NAa | 0.988 |
Nosocomial infection | 2.24 (0.87–5.80) | 0.096 | 2.62 (1.28–5.37) | 0.009 |  |  |
Trauma | 0.60 (0.18–1.97) | 0.398 | 0.66 (0.28–1.52) | 0.329 | 1.95 (0.50–7.56) | 0.335 |
Surgical operation | 1.20 (0.54–2.66) | 0.656 | 1.22 (0.69–2.17) | 0.493 |  |  |
Prior exposure to third- generation cephalosporins | 1.34 (0.68–2.63) | 0.399 | 1.23 (0.76–2.00) | 0.407 | 0.93 (0.41–2.10) | 0.853 |
Prior exposure to fluoroquinolones | 0.51 (0.22–1.22) | 0.129 | 0.66 (0.35–1.24) | 0.193 | 1.24 (0.44–3.51) | 0.683 |
Prior exposure to glycopeptides | 2.85 (1.20–6.77) | 0.018 | 2.86 (1.55–5.28) | 0.001 | 3.24 (1.08–9.67) | 0.035 |
CR-BSI | 0.92 (0.44–1.92) | 0.825 | 0.79 (0.47–1.32) | 0.360 |  |  |
Pneumonia | 0.37 (0.14–1.00) | 0.050 | 0.28 (0.14–0.59) | 0.001 | 2.15 (0.51–9.04) | 0.296 |
Severe sepsis or septic shock | 3.84 (1.85–7.96) | <0.001 | 3.64 (2.17–6.10) | <0.001 | 5.45 (2.14–13.87) | <0.001 |
Retention of foreign body | 1.63 (0.40–6.71) | 0.500 | 1.96 (0.62–6.18) | 0.250 |  |  |
Charlson’s comorbidity index (per 1-point increment) | 0.66 (0.57–0.77) | <0.001 | 0.68 (0.61–0.75) | <0.001 | 1.52 (1.27–1.83) | <0.001 |
Pitt’s bacteremia score (per 1-point increment) | 0.77 (0.64–0.93) | <0.001 | 0.76 (0.66–0.87) | <0.001 | 1.23 (0.99–1.54) | 0.067 |
Age (per 1-year increment) | 0.96 (0.94–0.98) | 0.001 | 0.97 (0.95–0.98) | <0.001 | 1.02 (1.00–1.05) | 0.105 |
Vancomycin MICs | 0.48 (0.20–1.16) | 0.103 | 0.42 (0.23–0.79) | 0.007 | 1.55 (0.52–4.62) | 0.433 |