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Table 5 Multivariate conditional logistic regression analysis of risk factors for in-hospital mortality in patients with healthcare-associated methicillin-resistant Staphylococcus aureus bacteremia in the propensity-matched analyses

From: Effects of inappropriate empirical antibiotic therapy on mortality in patients with healthcare-associated methicillin-resistant Staphylococcus aureus bacteremia: a propensity-matched analysis

 

Unmatched data set (n = 345)

Unmatched data set (IPTW, n = 345)

Matched data set (n = 254)

Independent variable

OR (95 % CI)

P-value

OR (95 % CI)

P-value

OR (95 % CI)

P-value

Inappropriate empirical antibiotic therapy

1.26 (0.64–2.48)

0.499

1.33 (0.83–2.12)

0.236

NAa

0.988

Nosocomial infection

2.24 (0.87–5.80)

0.096

2.62 (1.28–5.37)

0.009

  

Trauma

0.60 (0.18–1.97)

0.398

0.66 (0.28–1.52)

0.329

1.95 (0.50–7.56)

0.335

Surgical operation

1.20 (0.54–2.66)

0.656

1.22 (0.69–2.17)

0.493

  

Prior exposure to third- generation cephalosporins

1.34 (0.68–2.63)

0.399

1.23 (0.76–2.00)

0.407

0.93 (0.41–2.10)

0.853

Prior exposure to fluoroquinolones

0.51 (0.22–1.22)

0.129

0.66 (0.35–1.24)

0.193

1.24 (0.44–3.51)

0.683

Prior exposure to glycopeptides

2.85 (1.20–6.77)

0.018

2.86 (1.55–5.28)

0.001

3.24 (1.08–9.67)

0.035

CR-BSI

0.92 (0.44–1.92)

0.825

0.79 (0.47–1.32)

0.360

  

Pneumonia

0.37 (0.14–1.00)

0.050

0.28 (0.14–0.59)

0.001

2.15 (0.51–9.04)

0.296

Severe sepsis or septic shock

3.84 (1.85–7.96)

<0.001

3.64 (2.17–6.10)

<0.001

5.45 (2.14–13.87)

<0.001

Retention of foreign body

1.63 (0.40–6.71)

0.500

1.96 (0.62–6.18)

0.250

  

Charlson’s comorbidity index (per 1-point increment)

0.66 (0.57–0.77)

<0.001

0.68 (0.61–0.75)

<0.001

1.52 (1.27–1.83)

<0.001

Pitt’s bacteremia score (per 1-point increment)

0.77 (0.64–0.93)

<0.001

0.76 (0.66–0.87)

<0.001

1.23 (0.99–1.54)

0.067

Age (per 1-year increment)

0.96 (0.94–0.98)

0.001

0.97 (0.95–0.98)

<0.001

1.02 (1.00–1.05)

0.105

Vancomycin MICs

0.48 (0.20–1.16)

0.103

0.42 (0.23–0.79)

0.007

1.55 (0.52–4.62)

0.433

  1. CR-BSI catheter-related bloodstream infection, IPTW inverse probability of treatment weighted, OR odds ratio, 95 % CI 95 % confidence interval, MIC minimum inhibitory concentration, NA not available
  2. aThese variables were not available because they displayed perfect marginal homogeneity with respect to each category concerning inappropriate initial empirical antibiotic therapy