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Table 3 Hospital course and outcomes of Clostridium difficile infected patients who were treated with therapy including adjunctive intracolonic vancomycin compared to those who received therapy without intracolonic vancomycin

From: The efficacy of intracolonic vancomycin for severe Clostridium difficile colitis: a case series

 

Therapy with adjunctive intracolonic vancomycin

No. (%) or average ± s.d.

Therapy without intracolonic vancomycin

No. (%) or average ± s.d.

P value*

Total Number

26 (20.5 %)

101 (79.5 %)

 

Average Severity Score Index (range 0–9)

5.69 ± 1.4

5.02 ± 1.0

0.03

Length of hospital stay (days): average + SD

39.1 ± 30.6

27.1 ± 33.3

0.09

Death

10 (38.5)

39 (38.6 %)

1.00

Oral vancomycin

21 (80.8 %)

44 (43.6 %)

0.0008

Oral metronidazole

13 (50.0 %)

76 (75.2 %)

0.012

IV metronidazole

25 (96.2 %)

45 (44.6 %)

<0.0001

Admission to or transfer to the ICU

24 (92.3 %)

70 (69.3 %)

0.022

Fever (>101 ° F)

10 (38.5 %)

37 (33.7 %)

0.86

Ileus

12 (46.2 %)

29 (28.7 %)

0.10

Toxic megacolon

9 (34.6 %)

4 (4.0 %)

<0.0001

Colectomy

4 (15.4 %)

1 (1.0 %)

0.006

Recent VRE infection and/or colonization

7 (26.9 %)

6 (5.9 %)

0.005

Recent MRSA infection and/or colonization

10 (38.5 %)

14 (13.7 %)

0.007

  1. *Because of multiple hypotheses testing, a p value ≤ 0.01 determined statistical significance
  2. SD standard deviation, IV intravenous, ICU intensive care unit, VRE vancomycin resistant enterococcus, MRSA methicillin resistant Staphylococcus aureus