From: The efficacy of intracolonic vancomycin for severe Clostridium difficile colitis: a case series
 | Therapy with adjunctive intracolonic vancomycin No. (%) or average ± s.d. | Therapy without intracolonic vancomycin No. (%) or average ± s.d. | P value* |
---|---|---|---|
Total Number | 26 (20.5Â %) | 101 (79.5Â %) | Â |
Average Severity Score Index (range 0–9) | 5.69 ± 1.4 | 5.02 ± 1.0 | 0.03 |
Length of hospital stay (days): average + SD | 39.1 ± 30.6 | 27.1 ± 33.3 | 0.09 |
Death | 10 (38.5) | 39 (38.6Â %) | 1.00 |
Oral vancomycin | 21 (80.8Â %) | 44 (43.6Â %) | 0.0008 |
Oral metronidazole | 13 (50.0Â %) | 76 (75.2Â %) | 0.012 |
IV metronidazole | 25 (96.2Â %) | 45 (44.6Â %) | <0.0001 |
Admission to or transfer to the ICU | 24 (92.3Â %) | 70 (69.3Â %) | 0.022 |
Fever (>101 ° F) | 10 (38.5 %) | 37 (33.7 %) | 0.86 |
Ileus | 12 (46.2Â %) | 29 (28.7Â %) | 0.10 |
Toxic megacolon | 9 (34.6Â %) | 4 (4.0Â %) | <0.0001 |
Colectomy | 4 (15.4Â %) | 1 (1.0Â %) | 0.006 |
Recent VRE infection and/or colonization | 7 (26.9Â %) | 6 (5.9Â %) | 0.005 |
Recent MRSA infection and/or colonization | 10 (38.5Â %) | 14 (13.7Â %) | 0.007 |