Table 3 Efficacy (proportion of patients cured) in the study groups
Per lesion | Cryotherapy N = 327 (Protocol) | Control N = 257 (Protocol) | ||
Özgöztaslis O [19] | 93 (53/57) | 69.7 (23/33)a | ||
Gurei M [22] | 78 (47/60) | 92 (67/73)b | ||
Asilian A [21] | 57.2 (120/210) | 55.6 (84/151)a | ||
Overall (95 % CI) | 67.3 (62.0 – 72.5) | 67.7 (61.8 – 73.6) | ||
Per patient | Per Protocol N = 231 | Intent to treat N = 271 | Per Protocol N = 182 | Intent to treat N = 199 |
Salmanpour R [13] | 67.8 (14/20) | 75 (15/20)a | ||
Layegh P [10] | 58.3 (21/36) | 52.5 (21/40) | 27.8 (10/36)a | 25.6 (10/39)a |
López P [20] | 37.9 (25/66) | 28.4 (25/88) | 94.8 (73/77)a | 81.1 (73/90) a |
Negera E [14] | 93.3 (83/89) | 80.6 (83/103) | 89.5 (17/19)b | 85.0 (17/20)b |
Soto J [13] | 20 (4/20) | 70 (21/30)a | ||
Overall % (95 % CI) | 63.6 (57.2 – 70.1) | 54.2 (48.0 – 60.4) | 74.7 (68.1 – 81.3) | 68.3 (61.6 – 75.1) |