Table 5 Meta-analysis of the per patient efficacy of cryotherapy compared to pentavalent antimonials

Salmanpour R [15]

0.93 (0.64−1.37)

21.4

0.93 (0.64−1.37)

21.5

Layegh P [10]

2.10 (1.16−3.81)

18.6

2.05 (1.11−3.77)

18.6

López P [20]

0.40 (0.29−0.55)

22.2

0.35 (0.25−0.50)

21.9

Negera E [14]

1.04 (0.88−1.23)

23.5

0.95 (0.77−1.17)

23.2

Soto J [13]

0.29 (0.11−0.71)

14.3

0.29 (0.11−0.71)

14.7

Overall random effects

0.78 (0.45−1.34)

0.73 (0.42−1.29)

Sensitivity analysis

Relative change

Relative change

Salmanpour R [15]

0.73 (0.36−1.50)

−5.71

0.68 (0.33−1.45)

−7.04

Layegh P [10]

0.62 (0.35−1.11)

−19.9

0.58 (0.33−1.05)

−20.39

López P [20]

0.97 (0.62−1.55)

25.2

0.94 (0.59−1.48)

27.05

Negera E [14]

0.71 (0.33−1.53)

−9.3

0.67 (0.30−1.53)

−8.09

Soto J [13]

0.92 (0.52−1.61)

18.0

0.86 (0.48−1.56)

17.55

Overall random effects

0.78 (0.45−1.34)

0.73 (0.42−1.29)

Heterogeneity

Dersimonian- Laird's Q Statistic

42.69. p-value = 0.000

39.08. p-value = 0.000

RI Coefficient

0.934

0.889

Variation Coef.

4.259

2.468

Variance between studies

0,317

0,343

Variance within studies

0,022

0,031

No publication bias

Begg’s test, Z Statistic

0.2449. p-value = 0.806

0.2449. p-value = 0.403

Egger’s test, t Statistic

−1.0877. p-value = 0.356

0.7560. p-value = 0.505