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Table 3 Associations between the SNP genotypes of VDR and the risk of PTB

From: Vitamin D receptor gene associations with pulmonary tuberculosis in a Tibetan Chinese population

SNP-ID

Model

Genotype

Control (N,%)

Case (N,%)

OR (95 % CI)

p-value

p-adjusted

  

G/G

246 (64.6 %)

116 (53.5 %)

1

  
 

Codominant

A/G

120 (31.5 %)

87 (40.1 %)

1.54 (1.08-2.19)

0.024*

0.12

  

A/A

15 (3.9 %)

14 (6.5 %)

1.98 (0.92-4.24)

rs11574143

Dominant

G/G

246 (64.6 %)

116 (53.5 %)

1

  
  

G/A-A/A

135 (35.4 %)

101 (46.5 %)

1.59 (1.13-2.23)

0.0077*

0.039*

 

Recessive

G/G-G/A

366 (96.1 %)

203 (93.5 %)

1

  
  

A/A

15 (3.9 %)

14 (6.5 %)

1.68 (0.80-3.56)

0.18

0.90

 

Log-additive

---

---

---

1.48 (1.11-1.96)

0.0066*

0.033*

  

G/G

341 (89 %)

205 (94.5 %)

1

  
 

Codominant

A/G

41 (10.7 %)

12 (5.5 %)

0.49 (0.25-0.95)

0.053

0.265

  

A/A

1 (0.3 %)

0 (0 %)

0.00 (0.00-NA)

rs11574079

Dominant

G/G

341 (89 %)

205 (94.5 %)

1

  
  

A/G-A/A

42 (11 %)

12 (5.5 %)

0.48 (0.24-0.92)

0.021*

0.105

 

Recessive

G/G-A/G

382 (99.7 %)

217 (100 %)

1

  
  

A/A

1 (0.3 %)

0 (0 %)

0.00 (0.00-NA)

0.34

1

 

Log-additive

---

---

---

0.47 (0.25-0.91)

0.018*

0.09

  

G/G

168 (44.1 %)

43 (19.8 %)

1

  
 

Codominant

A/G

166 (43.6 %)

101 (46.5 %)

2.38 (1.57-3.60)

<0.0001*

<0.0005*

  

A/A

47 (12.3 %)

73 (33.6 %)

6.07 (3.69-9.97)

rs11168287

Dominant

G/G

168 (44.1 %)

43 (19.8 %)

1

  
  

A/G-A/A

213 (55.9 %)

174 (80.2 %)

3.19 (2.16-4.72)

<0.0001*

<0.0005*

 

Recessive

G/G-A/G

334 (87.7 %)

144 (66.4 %)

1

  
  

A/A

47 (12.3 %)

73 (33.6 %)

3.60 (2.38-5.46)

<0.0001*

<0.0005*

 

Log-additive

---

---

---

2.46 (1.92-3.15)

<0.0001*

<0.0005*

  1. OR odds ratio; CI confidence interval; *: p-value <0.05 indicates statistical significance. SNP single nucleotide polymorphism; VDR vitamin D receptor; PTB pulmonary tuberculosis