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Fig. 2 | BMC Infectious Diseases

Fig. 2

From: HIV-1 Tat protein vaccination in mice infected with Mycobacterium tuberculosis is safe, immunogenic and reduces bacterial lung pathology

Fig. 2

Tat vaccine administered to Mtb-infected mice reduces pulmonary infiltration and does not abrogate the protection conferred by BCG vaccination. Eight weeks post Mtb infection, bacteria in the lung (a) and spleen (b) were enumerated by CFU assay in mice treated as shown in Fig. 1. c Comparison of percentages of infiltrated area of sections of lung right lobes from the different mice groups. All data are expressed as mean of 6 individual mice/group ± SE. Statistical analysis was done by one-way ANOVA and Tukey’s multiple comparisons post-test *, P < 0.05, **, P < 0.01, ***, P < 0.001, differences respect to untreated Mtb-infected group. In panel C, the difference between BCG and BCG Tat-treated group is indicated. d Hematoxylin-eosin–stained sections of paraffin-embedded lungs from Mtb-infected mice killed at the 8 weeks post infection (upper panel) (magnification, ×2) and (lower panel) (magnification, ×40)

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