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Table 2 Clinical variables at time of hospital admission: comparison between DENV co-infections and mono-infections

From: Impact of dengue virus (DENV) co-infection on clinical manifestations, disease severity and laboratory parameters

Characteristic All patients
(n = 262) (%)
All mono-infections
(n = 222) (%)
All co-infectionsa
(n = 40) (%)
OR (95 % CI) DENV-1 mono-infections
(n = 170) (%)
DENV-1 co-infectionsb
(n = 39) (%)
OR (95 % CI) DENV-2 mono-infections
(n = 44) (%)
DENV-2 co-infectionsc
(n = 35) (%)
OR (95 % CI)
Secondary 82 (31.3) 70 (31.5) 12 (30) 0.931 (0.45-1.94) 59 (34.7) 12 (30.8) 0.84 (0.4-1.8) 10 (22.7) 8 (22.9) 1.01 (0.35-2.9)
Pediatric 38 (14.5) 30 (13.5) 8(20) 1.6 (0.67-3.80) 23 (13.5) 8 (20.5) 1.65 (0.68-4.03) 6 (13.6) 7 (20) 1.58 (0.48-5.23)
Age > 55 years 18 (6.9) 14 (6.3) 4 (10) 1.65 (0.51-5.30) 12 (7.1) 4 (10.3) 1.51 (0.46-4.94) 1 (2.3) 3 (8.6) 4.03 (0.40-40.57)
Male 146 (55.7) 123 (55.4) 23 (57.5) 1.09 (0.55-2.15) 89 (52.4) 22 (56.4) 1.18 (0.58-2.37) 29 (65.9) 21 (60.0) 0.78 (0.31-1.95)
Pregnancy 14 (5.3) 12 (5.4) 2 (5) 0.92 (0.2-4.28) 9 (5.3) 2 (5.1) 0.97 (0.20-4.66) 2 (4.5) 2 (5.7) 1.27 (0.17-9.52)
Comorbidity 52 (19.8) 45 (20.3) 7 (17.5) 0.83 (0.35-2.01) 38 (22.4) 6 (15.4) 0.63 (0.25-1.62) 7 (15.9) 6 (17.1) 1.09 (0.33-3.61)
Fever 260 (99.2) 220 (99.1) 40 (100) 1.18 (1.12-1.25) 169 (99.4) 39 (100) 1.23 (1.15-1.31) 43 (97.7) 35 (100) 1.81 (1.49-2.22)
Chills and rigors 117 (44.7) 101 (45.5) 16 (40) 0.80 (0.40-1.59) 78 (45.9) 15 (38.5) 0.74 (0.36-1.50) 18 (40.9) 15 (42.9) 1.08 (0.44-2.66)
Headache 125 (47.7) 102 (45.9) 23 (57.5) 1.59 (0.81-3.14) 78 (45.9) 22 (56.4) 1.53 (0.76-3.08) 20 (45.5) 20 (57.1) 1.6 (0.65-3.91)
Cough 30 (11.5) 28 (12.6) 2 (5) 0.37 (0.08-1.60) 20 (11.8) 2 (5.1) 0.41 (0.09-1.81) 8 (18.2) 2 (5.7) 0.27 (0.05-1.38)
Nausea 72 (27.5) 59 (26.6) 13 (32.5) 1.33 (0.64-2.75) 41 (24.1) 13 (33.3) 1.57 (0.74-3.34) 15 (34.1) 10 (28.6) 0.77 (0.30-2.03)
Vomit 164 (62.6) 141 (63.5) 23 (57.5) 0.78 (0.39-1.54) 111 (65.3) 22 (56.4) 0.69 (0.34-1.40) 26 (59.1) 20 (57.1) 0.92 (0.38-2.2)
Anorexia 101 (38.7) 83 (37.4) 18 (45) 1.37 (0.69-2.70) 61 (35.9) 18 (46.2) 1.53 (0.76-3.09) 21 (47.7) 16 (45.7) 0.92 (0.38-2.25)
Abdominal pain 103 (39.3) 91 (41.0) 12 (30) 0.62 (0.30-1.28) 73 (42.9) 12 (30.8) 0.59 (0.28-1.24) 16 (36.4) 9 (25.7) 0.61 (0.23-1.61)
Diarrhoea 120 (45.8) 109 (49.1) 11 (27.5) 0.39 (0.19-0.83)* 82 (48.2) 10 (25.9) 0.37 (0.17-0.81)* 23 (52.3) 9 (25.7) 0.32 (0.12-0.83)*
Myalgia 156 (59.5) 134 (60.4) 22 (55) 0.80 (0.41-1.58) 95 (55.9) 21 (53.8) 0.92 (0.46-1.85) 34 (77.3) 19 (54.3) 0.35 (0.13-0.92)*
Arthralgia 149 (56.9) 128 (57.7) 21 (52.5) 0.81 (0.41-1.60) 90 (52.9) 20 (51.3) 0.94 (0.47-1.88) 35 (79.5) 20 (57.1) 0.34 (0.13-0.93)*
Rash 39 (14.9) 35 (15.8) 4 (10) 0.59 (0.20-1.77) 23 (13.5) 4 (10.3) 0.73 (0.24-2.25) 11 (25) 4 (11.4) 0.39 (0.11-1.34)
Neurological 20 (7.6) 17(7.7) 3 (7.5) 0.98 (0.27-3.50) 14 (8.2) 3 (7.7) 0.93 (0.25-3.40) 2 (4.5) 2 (5.7) 1.27 (0.17-9.52)
Haemorrhagic symptoms 45 (17.2) 40(18.0) 5 (12.5) 0.65 (0.24-1.76) 34 (20) 5 (12.8) 0.59 (0.21-1.62) 2 (4.5) 4 (11.4) 2.71 (0.47-15.75)
Documented fever 189 (72.1) 159(71.6) 30 (75) 1.19 (0.55-2.58) 120 (70.6) 29 (74.4) 1.21 (0.55-2.67) 31 (70.5) 25 (71.4) 1.05 (0.39-2.79)
Tachypnoea 32 (12.3) 28(12.6) 4 (10) 0.77 (0.26-2.33) 20 (11.8) 4 (10.3) 0.86 (0.28-2.67) 8 (18.2) 4 (11.4) 0.58 (0.16-2.12)
Tachycardia 64 (24.4) 53(23.9) 11 (27.5) 1.21 (0.57-2.59) 47 (27.6) 11 (28.2) 1.03 (0.47-2.23) 6 (13.6) 10 (28.6) 2.53 (0.82-7.85)
Hypotension 22 (8.4) 20(9) 2 (5) 0.53 (0.12-2.37) 17 (10) 2 (5.1) 0.49 (0.11-2.20) 3 (6.8) 1 (2.9) 0.40 (0.04-4.04)
  1. Bold* type represents significance at p < 0.05
  2. aDENV-1/DENV-2 (n = 34), DENV-1/DENV-3 (n = 5), DENV-2/DENV-3 (n = 1); bDENV-1/DENV-2 (n = 34), DENV-1/DENV-3 (n = 5); cDENV-2/DENV-1 (n = 34), DENV-2/DENV-3 (n = 1)