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Table 4 Mutant H3N2 viruses with or without asparagine (N)-linked glycosylation site at residue 144 in hemagglutinin

From: Re-emergence of H3N2 strains carrying potential neutralizing mutations at the N-linked glycosylation site at the hemagglutinin head, post the 2009 H1N1 pandemic

Virus

Glycosylation sites in the HA globular head

63

122

126

133

144

165

246

H3-0 (7 NGSs)

NCT

NES

NWT

NGT

NKS

NVT

NCT

H3-1 (6 NGSs)

NCT

NES

NWT

NGT

NKA

NVT

NCT

  1. Residues 63, 122, 126, 133, 144, 165, and 246 are located in the globular head of hemagglutinin (HA)
  2. H3-0 virus has seven potential asparagine (N)-linked glycosylation sites (NGSs) in the HA globular head
  3. H3-1 is the mutant virus lacking NGS in the HA globular head at position 144; the mutation is produced by introducing a single amino acid substitution, namely, Ser (S) to Ala (A), at residue 146 of H3-0. Thus, H3-1 virus has six potential NGSs in the HA globular head