Table 2 Distribution of identified pneumococcal isolates. Two years (2007/2008) prior to PCV were compared to 3 years after (2011–2013). Of the total S. pneumoniae included in the present study, 78.8 % (n = 1234) were available for serotyping prior to and 79.2 % (n = 1352) after PCV introduction. p-values were calculated for relative incidences. Non-PHiD-CV10 serotypes that represent less than 2.5 % of serotypes before and after PCV introduction are grouped as “Others”

1

0.0 (1)

0.0 (0)

NA

4

1.8 (22)

0.4 (5)

<0.001

5

0.0 (1)

0.0 (0)

NA

6B

11.1 (137)

1.6 (21)

<0.001

7F

1.5 (19)

0.9 (12)

0.149

9V

1.6 (20)

0.7 (10)

0.043

14

6.4 (79)

1.8 (25)

<0.001

18C

2.2 (26)

1.3 (17)

0.093

19F

11.5 (141)

3.1 (42)

<0.001

23F

9.1 (112)

2.0 (28)

<0.001

Total PHiD-CV10 serotypes

45.2 (558)

11.8 (160)

<0.001

3

7.0 (86)

8.8 (119)

0.450

6A

9.1 (112)

3.3 (44)

<0.001

6C

2.9 (36)

6.7(91)

<0.001

10

0.7 (8)

2.9 (38)

<0.001

11A

4.0 (49)

10.0 (135)

<0.001

15B

2.1 (26)

9.3 (124)

<0.001

19A

3.7 (46)

9.9 (134)

<0.001

23A

3.0 (38)

6.4 (87)

<0.001

23B

0.3 (4)

4.2 (57)

<0.001

35

2.6 (32)

7.4 (100)

<0.001

Others^a

13.8 (170)

10.9 (148)

0.111

Total non-PHiD-CV10 serotypes

49.2 (607)

79.7 (1077)

<0.001

Non-typeable

5.6 (69)

8.6 (116)

<0.001