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Table 1 The Syrian hamster is more permissive to O. ochengi mf than BALB/c mice

From: Development and validation of an Onchocerca ochengi microfilarial hamster model for onchocerciasis drug screens

Animal

Sex (M/F)

Amount of O. ochengi mf injected

Percentage viability of mf at time of injection

Duration between mf injection and sacrifice (days)

No of mf in fore limbs

No of mf in hind limbs

No of mf in ear lobes

No of mf in tail

No of mf in head

No of mf in the trunk

Total mf recovered (% recovered)

% mf recovered in ear lobes relative to total recovery

Tissue and whole body pathology

Hamster 1

M

12,558

100 %

21

7

7

60

0

7

0

81 (0.65)

74.07

None observed

Hamster 2

M

44,100

88 %

21

125

100

600

67

117

130

1039 (2.36)

57.75

None observed

Hamster 3

M

25,000

100 %

30

27

7

353

0

67

53

507 (2)

69.63

None observed

BALB/c 1

M

25,000

100 %

15

120

20

390

20

610

180

1340 (5.36)

29.10

None observed

BALB/c 2

M

25,000

100 %

30

0

0

0

0

0

0

0 (0)

0

None observed

BALB/c 3

M

25,000

100 %

31

0

0

0

0

0

0

0 (0)

0

None observed

BALB/c 4

M

25,000

100 %

30

0

0

0

0

0

0

0 (0)

0

None observed

BALB/c 5

F

25,000

100 %

31

0

0

0

0

0

0

0 (0)

0

None observed

  1. Different numbers of O. ochengi mf isolated from cattle skin on different days were injected subcutaneously at the nape of different animal types and the animals were sacrificed on indicated days and analyzed for O. ochengi mf (n = 3–5/group)