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Table 2 Percentage of the multidrug-resistant P. aeruginosa isolates that were resistant, non-resistant, sensitive to imipenem, meropenem and doripenem in the presence and absence of 20 mg/L rifampicin

From: In vitro antibacterial activity of rifampicin in combination with imipenem, meropenem and doripenem against multidrug-resistant clinical isolates of Pseudomonas aeruginosa

 

Monotherapy

Combinations with RIF

IMP

MEM

DOR

IMP

MEM

DOR

(a) P. aeruginosa isolates without the carbapenemase (bla VIM) gene (65 isolates)

 Resistanta

100 % (65/65)

95.38 % (62/65)

86.15 % (56/65)

13.85 % (9/65)

43.08 % (28/65)

15.38 % (10/65)

 Non-resistantb

0 % (0/65)

4.62 % (3/65)

13.85 % (9/65)

86.15 % (56/65)

56.92 % (37/65)

84.62 % (55/65)

 Sensitivec

0 % (0/65)

0 % (0/65)

1.54 % (1/65)

73.85 % (48/65)

47.69 % (31/65)

47.69 % (31/65)

(b) P. aeruginosa isolates with the carbapenemase (bla VIM) gene (6 isolates)

 Resistanta

100 % (6/6)

100 % (6/6)

100 % (6/6)

83.33 % (5/6)

83.33 % (5/6)

66.67 % (4/6)

 Non-resistantb

0 % (0/6)

0 % (0/6)

0 % (0/6)

16.67 % (1/6)

16.67 % (1/6)

33.33 % (2/6)

 Sensitivec

0 % (0/6)

0 % (0/6)

0 % (0/6)

0 % (0/6)

0 % (0/6)

0 % (0/6)

  1. aResistant (MIC >4 mg/L), bNon-resistant (MIC ≤4 mg/L), cSensitive (MIC ≤2 mg/L)
  2. VIM Verona integron-encoded metallo-β-lactamase, IPM imipenem, MEM meropenem, DOR doripenem, RIF rifampicin