Table 1 Case mix of admissions by invasive fungal disease subgroup
Candida albicans IFD | Non-albicans Candida spp. IFD | No IFD | |
|---|---|---|---|
Number of admissions | 235 | 106 | 60,362 |
Demographics | |||
Age (years), median (IQR) | 61 (49, 71) | 62 (50, 73) | 64 (48, 74) |
Male sex, n (%) | 123 (52.3) | 60 (56.6) | 33,613 (55.7) |
Medical history, n (%) | |||
Severe comorbidities | |||
Any severe comorbidity | 34 (14.5) | 27 (25.5) | 10,142 (17.0) |
Very severe cardiovascular disease | 2 (1.3) | 4 (5.1) | 1021 (2.5) |
Severe respiratory disease | 5 (3.2) | 1 (1.3) | 1650 (4.0) |
Chronic renal disease | 6 (3.8) | 2 (2.6) | 1122 (2.7) |
Chronic liver disease | 9 (5.7) | 6 (7.6) | 1909 (4.7) |
Metastatic disease | 2 (1.3) | 1 (1.3) | 1421 (3.5) |
Haematological malignancy | 3 (1.9) | 5 (6.4) | 1064 (2.6) |
Immunocompromised | 16 (10.2) | 14 (18.0) | 4092 (10.0) |
Diabetes mellitus | 36 (15.3) | 20 (18.9) | 9608 (15.9) |
Neutropenia | 7 (3.7) | 2 (2.5) | 930 (1.8) |
Surgery within up to 7 days prior to admission, n (%) | |||
Emergency/urgent | 91 (38.7) | 29 (27.4) | 13,127 (21.7) |
Scheduled/elective | 27 (11.5) | 15 (14.2) | 14,987 (24.8) |
No surgery | 117 (49.8) | 62 (58.5) | 32,230 (53.4) |
Acute severity of illness, mean (SD) | |||
APACHE II Score | 19.0 (6.6) | 19.6 (7.5) | 16.0 (7.0) |
ICNARC Physiology Score | 23.1 (8.8) | 22.4 (9.2) | 17.3 (9.3) |
Primary reason for admission to the critical care unit, n (%) | |||
Medical | 126 (51.3) | 60 (62.5) | 32,114 (52.2) |
Respiratory | 52 (22.4) | 24 (23.1) | 12,022 (21.0) |
Cardiovascular | 28 (12.1) | 11 (10.6) | 5622 (9.8) |
Gastrointestinal | 15 (6.5) | 13 (12.5) | 2519 (4.4) |
Neurological | 6 (2.6) | 1 (1.0) | 4697 (8.2) |
Other | 25 (10.8) | 11 (10.6) | 7254 (12.7) |
Surgical | 118 (50.2) | 44 (41.5) | 28,131 (46.6) |
Cardiovascular | 76 (32.8) | 37 (35.6) | 13,280 (23.2) |
Gastrointestinal | 13 (5.6) | 5 (4.8) | 4201 (7.3) |
Other | 17 (7.2) | 2 (1.9) | 7601 (13.3) |
Mortality, deaths (%) | |||
Critical care unit mortality | 82 (34.9) | 30 (28.3) | 10,047 (16.6) |
Acute hospital mortality | 93 (49.5) | 42 (47.7) | 13,926 (24.5) |
Length of stay (days), median (IQR) | |||
Critical care unit stay | 12 (6, 24) | 11 (5, 25) | 2 (1, 5) |
Unit survivors | 12 (6, 25) | 12 (6, 26) | 2 (1, 5) |
Unit non-survivors | 12 (7, 23) | 10 (3, 25) | 2 (1, 6) |
Acute hospital stay | 33 (15, 58) | 40 (20, 73) | 13 (6, 27) |
Acute hospital survivors | 48 (31, 79) | 51 (34, 82) | 14 (7, 29) |
Acute hospital non-survivors | 19 (11, 42) | 29 (10, 63) | 8 (2, 19) |