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Table 4 Odds ratios for univariate (unadjusted) and multivariate (adjusted) logistic regression models predicting the development of prolonged TB-IRIS (n = 181)

From: Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors

 

Unadjusted OR (95 % CI)

Unadjusted p-value

Adjusted OR (95 % CI)

Adjusted p-value

Age (per 1 year increase)

0.97 (0.93–1.01)

0.16

0.98 (0.94–1.05)

0.48

Male gender

0.72 (0.38–1.35)

0.31

0.80 (0.39–1.63)

0.54

Lymph node involvement at initial TB diagnosis

2.36 (1.18–4.76)

0.02

1.79 (0.81–3.98)

0.15

Drug-resistant TBa

4.13 (1.32–15.56)

0.02

3.26 (0.97–12.99)

0.07

Hospitalised at time of TB-IRIS diagnosis

0.40 (0.22–0.75)

0.004

0.5 (0.25–0.99)

0.05

TB-IRIS lymph node involvement

3.01 (1.63–5.65)

0.0005

2.27 (1.13–4.59)

0.02

TB-IRIS pulmonary involvement

0.54 (0.29–1.02)

0.06

0.65 (0.32–1.30)

0.23

Cohort 2b

0.06 (0.01–0.18)

< 0.0001

Not included

 

Cohort 1b

0.29 (0.12–0.62)

0.002

Not included

 
  1. Abbreviations: IRIS immune reconstitution inflammatory syndrome, TB tuberculosis
  2. aThe reference group is combined culture negative, culture not done and drug susceptible
  3. bReference cohort was randomized controlled trial