Skip to main content

Table 3 Geographical information, phylogenic lineage, drug resistance pattern, and their association with strain clustering

From: Drug resistance and population structure of M.tuberculosis isolates from prisons and communities in Ethiopia

Variables

Unique strains (n)

Clustered strains (n)

COR (95% CI)

p-value*

AOR (95% CI)

p-value$

Regions

 Oromia

14

2

1

   

 SNNPRS

32

17

3.72(0.76,18.31)

0.11

6.19 (0.92,41.83)

0.06

 Dire Dawa

7

3

3.00(0.40,22.30)

0.28

3.98(0.35,44.90)

0.26

 Harar

11

3

1.91(0.27,13.50)

0.52

1.36(0.15,12.70)

0.79

 Somali

11

9

5.73(1.02,32.10)

0.04

8.76(1.07,71.88)

0.04

Lineage

 Delhi/CAS

14

4

1

   

 Ethiopia_H37Rv like

23

7

1.07(0.26,4.31)

0.93

1.20(0.28,5.20)

0.81

 Euro-American Superlineage

11

6

1.91(0.43,8.48)

0.40

1.76(0.37,8.41)

0.48

 LAM

2

2

3.50(0.37,33.31)

0.28

5.46(0.46,64.04)

0.18

 Ethiopia_3

8

10

4.38(1.03,18.63)

0.05

8.72(1.69,45.02)

0.01

 Haarlem

3

5

5.83(0.95,35.72)

0.06

7.88(0.98,63.23)

0.05

 Others

14

0

-

-

  

Streptomycin

 Resistant

13

4

1

   

 Susceptible

61

29

1.55(0.46,5.150)

0.48

NA

NA

Isoniazide

 Resistant

7

1

1

   

 Susceptible

68

33

3.39(0.40,28.76)

0.26

NA

NA

Rifampicin

 Resistant

5

1

1

   

 Susceptible

70

33

2.36(0.26,20.98)

0.44

NA

NA

Ethambutol

 Resistant

4

1

1

   

 Susceptible

70

33

1.89(0.20,17.54)

0.58

NA

NA

MDR

 Yes

3

1

1

   

 No

72

33

1.37(0.14,13.72)

0.79

NA

NA

Any resistance

 Yes

19

4

1

   

 No

56

30

2.54(0.79,8.16)

0.12

NA

NA

  1. n = numbers of clustered (i.e., isolates sharing identical MIRU-24 and spoligotyping patterns with at least one other isolate) or unique (i.e., isolates that do not share their MIRU-24 and spoligotyping pattern with any other isolate) strains in each stratum
  2. COR = crude odds ratio
  3. AOR = adjusted odds ratio: significant variables in the crude analysis were adjusted for age, region and genotype
  4. NA = not applicable
  5. * = p-value for univariate regression model
  6. $ = p-value for multivariate regression model