Fig. 1

CNS-IRIS case timeline. On top, a timeline of the clinical evolution shows the temporal relation between toxoplasmosis CNS-IRIS symptoms onset (yellow arrow); the routine medical appointment followed by hospital admission (pink arrow) and the beginning of the clinical recovery (green arrow). Blue asterisks mark the five time-points when complete clinical and laboratorial evaluation was performed and blood samples were collected for flow cytometry analysis. On bottom left, brain CT performed at the initial diagnosis of toxoplamosis. On bottom right, spinal cord MRI performed after hospital admission. ^{a, b)} See Additional file 1: Figure S3 and S4, respectively. ^c) Suppressive therapy: long-term, low-dose anti-toxoplasma therapy to prevent further recurrent episodes