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Table 5 Parameters for disposition of asexual parasitaemia in children with or without early rising asexual parasitaemia following artemisinin-based combination treatments

From: Early rising asexual parasitaemia in Nigerian children following a first dose of artemisinin-based combination treatments of falciparum malaria

Parameters

Early rising asexual parasitaemia

P value

Yes (n = 205)

No (n = 211)

All (n = 416)

Cmaxpd (μL−1)

 Geometric mean

91,502

61,639

74,887

0.01

 Range

3,465-838,500

1,800-1,096,636

1,800-1,096,636

Tmaxpd (h)

 Mean

2.6

0.2

1.4

<0.0001

 95% CI

2.3–2.9

0.1–0.3

1.2–1.6

AUCpd (μL−1.h)

   

<0.0001

 0-4 h (Geometric mean)

2.6 × 105

1.5 × 105

2.0 × 105

 Range

1.0 × 104–3.1 × 106

1.6 × 103–2.2 × 106

1.6 × 103–3.1 × 106

 0–8 h (Geometric mean)

5.3 × 105

2.7 × 105

3.9 × 105

0.001

 Range

2.0 × 104–5.9 × 106

2.2 × 103–2.4 × 106

2.2 × 103–5.9 × 106

 0–24 h (Geometric mean)

7.8 × 105

3.6 × 105

5.3 × 105

<0.0001

 Range

2.9 × 104–1.1 × 107

2.7 × 103–4.1 × 106

2.7 × 103–1.1 × 107

 0–48 h (Geometric mean)

7.9 × 105

3.7 × 105

5.4 × 105

<0.0001

 Range

2.9 × 104–1.1 × 107

2.7 × 103–4.5 × 106

2.7 × 103–1.1 × 107

 0–∞ (Geometric mean)

8.0 × 105

3.7 × 105

5.4 × 105

<0.0001

 Range

2.9 × 104–1.1 × 107

2.7 × 103–4.5 × 106

2.7 × 103–1.1 × 107

CLBpd (Lh−1)

 Mean

0.1

0.4

0.3

<0.0001

 95% CI

0.1–0.2

0.3–0.4

0.2–0.3

Elimination half-time (h)

 Mean

1.2

1.2

1.2

0.6

 95% CI

1.1–1.3

1.1–1.2

1.1–1.2

Elimination rate constant (h−1)

 Mean

0.6

0.6

0.6

0.9

 95% CI

0.6–0.7

0.6–0.7

0.6–0.7

  1. h hour, C maxpd maximum asexual parasite density (concentration), T maxpd time to reach maximum asexual parasite density (concentration), CL Bpd volume of blood cleared of parasitaemia per unit of time, AUC pd area under curve of plot of parasite density (parasitaemia) versus time