Parameters | Early rising asexual parasitaemia | P value | ||
---|---|---|---|---|
Yes (n = 205) | No (n = 211) | All (n = 416) | ||
Cmaxpd (μL−1) | ||||
 Geometric mean | 91,502 | 61,639 | 74,887 | 0.01 |
 Range | 3,465-838,500 | 1,800-1,096,636 | 1,800-1,096,636 | |
Tmaxpd (h) | ||||
 Mean | 2.6 | 0.2 | 1.4 | <0.0001 |
 95% CI | 2.3–2.9 | 0.1–0.3 | 1.2–1.6 | |
AUCpd (μL−1.h) |  |  |  | <0.0001 |
 0-4 h (Geometric mean) | 2.6 × 105 | 1.5 × 105 | 2.0 × 105 | |
 Range | 1.0 × 104–3.1 × 106 | 1.6 × 103–2.2 × 106 | 1.6 × 103–3.1 × 106 | |
 0–8 h (Geometric mean) | 5.3 × 105 | 2.7 × 105 | 3.9 × 105 | 0.001 |
 Range | 2.0 × 104–5.9 × 106 | 2.2 × 103–2.4 × 106 | 2.2 × 103–5.9 × 106 | |
 0–24 h (Geometric mean) | 7.8 × 105 | 3.6 × 105 | 5.3 × 105 | <0.0001 |
 Range | 2.9 × 104–1.1 × 107 | 2.7 × 103–4.1 × 106 | 2.7 × 103–1.1 × 107 | |
 0–48 h (Geometric mean) | 7.9 × 105 | 3.7 × 105 | 5.4 × 105 | <0.0001 |
 Range | 2.9 × 104–1.1 × 107 | 2.7 × 103–4.5 × 106 | 2.7 × 103–1.1 × 107 | |
 0–∞ (Geometric mean) | 8.0 × 105 | 3.7 × 105 | 5.4 × 105 | <0.0001 |
 Range | 2.9 × 104–1.1 × 107 | 2.7 × 103–4.5 × 106 | 2.7 × 103–1.1 × 107 | |
CLBpd (Lh−1) | ||||
 Mean | 0.1 | 0.4 | 0.3 | <0.0001 |
 95% CI | 0.1–0.2 | 0.3–0.4 | 0.2–0.3 | |
Elimination half-time (h) | ||||
 Mean | 1.2 | 1.2 | 1.2 | 0.6 |
 95% CI | 1.1–1.3 | 1.1–1.2 | 1.1–1.2 | |
Elimination rate constant (h−1) | ||||
 Mean | 0.6 | 0.6 | 0.6 | 0.9 |
 95% CI | 0.6–0.7 | 0.6–0.7 | 0.6–0.7 |