Table 6 Features of children with or without early rising asexual parasitaemia matched for gender, enrolment parasitaemia, treatment and same day presentation who were treated with artesunate-amodiaquine, artemether-lumefantrine or dihydroartemisinin-piperaquine

 Mean

38.3

38

38.1

0.07

 95% CI

38.1–38.6

37.7–38.3

37.9–38.3

Fever on day 1

9

5

14

0.27

 Mean

1.1 (n = 66)

1.1 (n = 52)

1.1 (n = 118)

0.59

 95% CI

1–1.2

1–1.2

1–1.1

 At enrolment (0 h)

61,165

59,853

60,505

0.96

 Range

2,928–536,912

2,000–500,000

2,000–536,912

 1 h

74,268

39,865

55,059

0.001

 Range

2, 136–763,500

790–314,030

790–763,500

 2 h

71,410

30,689

46567

<0.0001

 Range

2,976–838,500

284–313,980

284–838,500

 4 h

57,650

24,043

38,394

<0.0001

 Range

210–785,610

339–253,304

210–785,610

 6 h

33,950

9,604

18,312

0.02

 Range

980–531,000

321–133,400

321–531,000

 8 h

37,017

8,052

16,919

0.002

 Range

656–616,119

106–266,400

106–616,119

 On day 1 [%]

18 [21]

13 [15]

31 [20]

0.32

 On day 3 [%]

1 [1]

1 [1]

2 [1]

1.0

 Geometric mean

1.6 × 10⁴

2.7 × 10⁴

2.1 × 10⁴

0.68

 Range

6.5 × 10⁻¹–5.4 × 10⁵

9.8 × 10⁰–5.0 × 10⁵

6.5 × 10⁻¹–5.4 × 10⁵

 Geometric mean

6.1 × 10⁴

5.6 × 10⁴

5.9 × 10⁴

0.78

 Range

2.9 × 10³–5.4 × 10⁵

6.0 × 10²–5.0 × 10⁵

6.0 × 10²–5.4 × 10⁵

 Mean

29.6

28.5

29.1

0.53

 95% CI

27–32.3

26.1–30.9

27.3–30.9

Anaemia on day 1

29

22

51

0.22

 Mean

13.2 (n = 21)

10.6 (n = 24)

11.6 (n = 44)

0.25

 95% CI

10.5–15.9

6.8–14.4

9.2–13.9

No. with late-appearing anaemia

12

9

21

0.64