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Table 2 Outcomes in hyponatremic and normonatremic patients

From: Hyponatremia is a marker of disease severity in HIV-infected patients: a retrospective cohort study

Characteristics

Total (N = 1196)

Na < 135 mmol/l (N = 177)

Na ≥ 135 mmol/l (N = 1019)

P-value

Combined antiretroviral therapy (n)

845 (70.6%)

130 (73.4%)

715 (70.2%)

0.421

Follow-up (months)a

36.0 (9.0-80.0)

41.0 (4.0-115.0)

35.0 (10.0-77.0)

0.554

Loss to follow-up/100 patient-years (95% CI)

8.2 (7.5-9.1)

8.4 (7.4-9.1)

8.2 (6.5-10.6)

0.870

Deaths (n)

63 (5.3%)

24 (13.5%)

39 (3.8%)

<0.0001

Death rate/1000 patient-years (95% CI)

12.5 (9.6-16.0)

28.3 (18.1-42.2)

9.33 (6.6-12.7)

<0.0001

Hospitalization rate/1000 patient-years (95% CI)

440 (422–458)

785 (725–845)

370 (252–388)

<0.0001

Mean number of hospitalizations per patient (n)b

2.2 ± 4.9

4.3 ± 9.5

1.8 ± 3.3

<0.0001

Median time to death (months)a

12.0 (3.0-34.0)

6.0 (2.0-22.5)

14.0 (4.0-39.0)

0.169

Median time to first hospitalization (months)a,c

12.0 (2.0-28.0)

2.0 (0.0-12.0)

13.0 (2.0-29.0)

0.0012

  1. amedian (interquartile range)
  2. bmean ± standard deviation
  3. cexcluding patients hospitalized at first contact