From: Hyponatremia is a marker of disease severity in HIV-infected patients: a retrospective cohort study
Characteristics | Total (N = 1196) | Na < 135 mmol/l (N = 177) | Na ≥ 135 mmol/l (N = 1019) | P-value |
---|---|---|---|---|
Combined antiretroviral therapy (n) | 845 (70.6%) | 130 (73.4%) | 715 (70.2%) | 0.421 |
Follow-up (months)a | 36.0 (9.0-80.0) | 41.0 (4.0-115.0) | 35.0 (10.0-77.0) | 0.554 |
Loss to follow-up/100 patient-years (95% CI) | 8.2 (7.5-9.1) | 8.4 (7.4-9.1) | 8.2 (6.5-10.6) | 0.870 |
Deaths (n) | 63 (5.3%) | 24 (13.5%) | 39 (3.8%) | <0.0001 |
Death rate/1000 patient-years (95% CI) | 12.5 (9.6-16.0) | 28.3 (18.1-42.2) | 9.33 (6.6-12.7) | <0.0001 |
Hospitalization rate/1000 patient-years (95% CI) | 440 (422–458) | 785 (725–845) | 370 (252–388) | <0.0001 |
Mean number of hospitalizations per patient (n)b | 2.2 ± 4.9 | 4.3 ± 9.5 | 1.8 ± 3.3 | <0.0001 |
Median time to death (months)a | 12.0 (3.0-34.0) | 6.0 (2.0-22.5) | 14.0 (4.0-39.0) | 0.169 |
Median time to first hospitalization (months)a,c | 12.0 (2.0-28.0) | 2.0 (0.0-12.0) | 13.0 (2.0-29.0) | 0.0012 |