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Table 1 Baseline characteristics of study population

From: Cocaine/crack use is not associated with fibrosis progression measured by AST-to-Platelet Ratio Index in HIV-HCV co-infected patients: a cohort study

 

Total (N = 573)

Recent cocaine/crack use (N = 211)

Previously used cocaine/crack; not recent (N = 290)

Never used cocaine/crack (N = 72)

Follow-up time (years)a

2.3 (1.0, 4.1)

2.1 (1.0, 3.9)

2.4 (1.1, 4.5)

2.0 (0.8, 4.4)

Age (years)

44 (38, 49)

43 (38, 49)

44 (38, 48)

47 (40, 53)

Female

173 (30%)

69 (33%)

81 (28%)

23 (32%)

Aboriginal

86 (15%)

53 (25%)

31 (11%)

2 (3%)

Time since HIV diagnosis (years)

10 (5, 16)

10 (5, 14)

10 (6, 16)

13 (5, 20)

Duration HCV infection (years)

18 (10, 25)

19 (12, 26)

18 (11, 25)

10 (4, 20)

CD4 cell count (cells/μL)

389 (253, 550)

360 (220, 528)

390 (260, 550)

439 (300, 601)

HIV RNA load ≤ 50 copies/mL

340 (59%)

117 (55%)

175 (60%)

48 (67%)

Time since first start of ART (years)

6 (2, 11)

6 (2, 10)

6 (3, 11)

9 (2, 12)

cART regimen

453 (79%)

164 (78%)

227 (78%)

62 (86%)

Prior AIDS diagnosis

162 (28%)

65 (31%)

77 (27%)

20 (28%)

APRI

0.5 (0.4, 0.8)

0.5 (0.4, 0.7)

0.6 (0.4, 0.8)

0.6 (0.4, 1.0)

HCV RNA (log10 UI/mL)b

6.2 (5.4, 6.7)

6.1 (5.1, 6.6)

6.2 (5.5, 6.8)

6.2 (5.6, 6.7)

HCV treatment naïve

512 (89%)

197 (93%)

258 (89%)

57 (79%)

Alcohol abusec

83 (14%)

41 (19%)

37 (13%)

5 (7%)

  1. a: Median (IQR) or Number (%)
  2. b: For HCV RNA only 307 (86/211 (41%) recent cocaine/crack users, 170/290 (59%) previous/not recent cocaine/crack users, and 51/72 (71%) non cocaine/crack users) had available quantitative HCV RNA values
  3. c: Defined as >6 drinks at least once a month and >2 drinks on a typical day when drinking