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Table 2 Analysis of potential risk factors for excessively prolonged meropenem therapy

From: Risk factors for excessively prolonged meropenem use in the intensive care setting: a case-control study

  

Univariate logistic regression

Multivariate logistic regression

OR

95 % CI

P-value

OR

95% CI

P-value

age

<50

1

 

0.44

-

-

-

50-70

0.72

0.25–2.04

≥70

0.49

0.16–1.53

sex

male

1

 

0.76

-

-

-

female

1.13

0.51–2.49

malignancy

No

1

 

0.002

1

 

0.84

Yes

3.5

1.57–7.82

1.14

0.32–4.06

SAPS at admission

<40

1

 

0.33

-

-

-

≥40

1.45

0.68–3.11

patient group

medical

1

 

<0.001

1

 

0.31

neurological

2.41

0.63–9.30

2.79

0.65 – 11.92

surgical

8.36

2.67–26.17

2.46

0.50 – 11.98

colonization with carbapenem-susceptible, MDR bacteria

no

1

 

0.01

1

 

0.004

yes

4.12

1.38–12.35

7.52

1.88–30.14

type of infection

pneumonia

1

 

<0.001

1

 

<0.001

peritonitis

21.60

5.05–92.35

16.96

2.95 – 97.49

mediastinitis

10.12

1.96–52.41

6.27

0.81 – 48.76

unclear focus

0.94

0.27–3.24

0.77

0.21 – 2.84

  1. Full model containing all variables with at least some evidence of association (p < 0.1) with the outcome in univariate regression analysis
  2. Abbreviations: MDR multidrug-resistant; OR: odds ratio; 95% CI: 95% confidence Interval