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Table 3 Risk factors for bacteremia-related mortality in ASOT recipients with MDR GNB

From: Factors influencing mortality in abdominal solid organ transplant recipients with multidrug-resistant gram-negative bacteremia

Characteristics

Related mortality

Survival

P

OR (95% CI)

 Total, n (%)

36 (39.6)

55 (60.4)

  

Univariate analysis

 Age ≥ 40 year

25 (69.4)

35 (63.6)

0.568

 

 Male sex

24 (66.7)

38 (69.1)

0.808

 

 Temperature ≥ 40 °C

8 (22.2)

4 (7.3)

0.039

 

 Inappropriate empirical antibiotics

14 (38.9)

20 (36.4)

0.808

 

 Nosocomial infection

35 (97.2)

39 (70.9)

0.002

 

 Graft from DCD or deceased donors

17 (47.2)

39 (70.9)

0.023

 

 Liver transplant

20 (55.6)

24 (43.6)

0.266

 

 Lung focus

22 (61.1)

15 (27.3)

0.001

 

 Presence of other concomitant BSIs

22 (61.1)

13 (23.6)

<0.001

 

 Non-fermentative bacteremia

18 (50.0)

18 (32.7)

0.099

 

 ESBL (+) bacteremia

31 (86.1)

42 (76.4)

0.254

 

 Carbapenem-resistant bacteremia

16 (44.4)

22 (40.0)

0.674

 

 Late-onset infection

12 (33.3)

17 (30.9)

0.808

 

 Septic shock

28 (77.8)

5 (9.1)

<0.001

 

 Platelet count < 50,000/mm3

26 (72.2)

13 (23.6)

<0.001

 

 Lymphocyte count < 300/mm3

17 (47.2)

15 (27.3)

0.051

 

 Albumin < 30 g/L

11 (30.6)

5 (9.1)

0.009

 

 WBC count > 15,000/mm3

12 (33.3)

15 (27.3)

0.277

 

 Creatinine > 1.5 mg/dL

23 (63.9)

19 (34.5)

0.006

 

Multivariate analysis

 Presence of other concomitant BSIs

  

0.001

27.074 (3.937–186.210)

 Nosocomial infection

  

0.033

23.963 (1.285–446.991)

 Creatinine > 1.5 mg/dL

  

0.001

24.498 (3.449–173.998)

 Septic shock

  

<0.001

160.463 (19.377–1328.832)

  1. ASOT abdominal solid organ transplant, DCD donation after cardiac death, ESBL extended-spectrum beta-lactamase, MDR multidrug-resistant, GNB gram-negative bacteria, OR odds ratio, CI confidence interval, BSIs bloodstream infections, WBC white blood cells