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Table 1 Overall sensitivity of the urine LAM using random versus EMU samples, and stratified by diagnostic category and preceding anti-TB treatment

From: Early morning urine collection to improve urinary lateral flow LAM assay sensitivity in hospitalised patients with HIV-TB co-infection

Sensitivity

95% (CI)

Manufacturer recommended LF-LAM positive cut point (grade 2)

P-value

Random Urine

%, 95% CI, n/N

Early Morn. Urine

%, 95% CI, n/N

Definite- TB only

12

(5–24)

(5/41)

39

(26–54)

(16/41)

0.005

Probable TB only

9.6

(5–17)

8/82

24

(16–34)

20/82

0.001

Definite and Probable TB combined

10

(6–17)

(13/123)

30

(22–38)

(36/123)

<0.001

No TB Rx prior

11

(4–28)

(3/27)

31

(17–50)

(8/26)

0.05

TB Rx prior

<7 days

10

(2–40)

(1/10)

56

(27–81)

(5/9)

0.04

No TB Rx prior

15

(8–27)

(8/52

25

(15–38)

(13/52)

0.1

TB Rx prior

< 7 day

0

(0–11)

(0/30)

23

(12–41)

(7/30)

0.003

No TB Rx prior

14

(8–23)

(11/79)

30

(18–38)

(21/78)

0.03

TB Rx prior

< 7 days

2

(0–12)

(1/42)

30

(18–45)

(12/40)

<0.001