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Table 1 Clinical characteristics of the study participants

From: Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study

  N-NS (n=179) S-NS (n=191) P a S-NS P b P c P d
Confirmed (n=123) Probable (n=68)
Male 112 (62.6%) 149 (78.0%) 0.001 97 (78.9%) 52 (76.5%) 0.702 0.003 0.039
  P50 (P25-P75)e P50 (P25-P75)   P50 (P25-P75) P50 (P25-P75)    
Age 54 (45-64) 53 (46-61) 0.661 52 (46-60) 55 (45-64) 0.373 0.474 0.869
Serum RPR titer 1:1 (Negative-1:2) 1:16 (1:4-1:64) <0.001 1:32 (1:16-1:64) 1:2 (1:1-1:8) <0.001 <0.001 <0.001
Serum TPPA titer 1:640 (1:320-1:1280) 1:10240 (1:2560-1:20480) <0.001 1:20480 (1:10240-1:20480) 1:2560 (1:1280-1:5120) <0.001 <0.001 <0.001
CSF RPR titer Negative 1:2 (Negative-1:4) <0.001 1:4 (1:2-1:8) Negative <0.001 <0.001 1.0
CSF TPPA titer Negative 1:1280 (1:160-1:5120) <0.001 1:5120 (1:1280-1:10240) 1:80 (1:80-1:640) <0.001 <0.001 <0.001
CSF leukocyte (cells/μL) 4 (2-7) 15 (6-48) <0.001 29 (12-59) 6 (2-13) <0.001 <0.001 0.015
CSF protein (mg/L) 390.9 (289.9-540.0) 606.0 (418.6-884.3) <0.001 733.9 (502.0-1025.0) 443.1 (325.8-607.2) <0.001 <0.001 0.183
CSF albumin (mg/L) 249.0 (173.7-361.9) 296.4 (220.0-456.2) 0.003 296.4 (243.0-500.6) 297.0 (182.7-446.2) 0.218 0.001 0.204
CSF glucose (mmol/L) 3.70 (3.40-4.20) 3.54 (3.21-4.19) 0.037 3.48 (3.12-4.08) 3.74 (3.25-4.20) 0.030 0.003 0.913
CSF chloride (mmol/L) 124.3 (121.9-126.4) 124.4 (121.5-126.3) 0.696 124.8 (121.5-126.5) 123.9 (121.6-125.9) 0.303 0.902 0.330
CSF lactate (mmol/L) 1.76 (1.57-2.02) 1.89 (1.67-2.17) 0.043 1.90 (1.73-2.30) 1.83 (1.66-2.06) 0.160 0.018 0.516
CSF lactate dehydrogenase (U/L) 20.2 (16.7-27.7) 20.2 (16.0-26.5) 0.696 19.5 (16.0-23.6) 22.2 (17.8-34.1) 0.032 0.131 0.184
Intracranial pressure (mmH2O) 135 (110-160) 140 (110-160) 0.604 140 (110-160) 140 (100-160) 0.882 0.656 0.692
  1. N-NS syphilis/non-neurosyphilis, S-NS symptomatic neurosyphilis, RPR rapid plasma reagin, TPPA T. pallidum particle agglutination, CSF cerebrospinal fluid, P a Comparison between the S-NS group and the N-NS group, P b Comparison between the confirmed neurosyphilis subgroup and the probable neurosyphilis subgroup, P c Comparison between the confirmed neurosyphilis subgroup and the N-NS, P d Comparison between the probable neurosyphilis subgroup and the N-NS
  2. eData with skewed distribution was described using median (interquartile range)