| |
N-NS (n=179)
|
S-NS (n=191)
|
P
a
|
S-NS
|
P
b
|
P
c
|
P
d
|
|---|
|
Confirmed (n=123)
|
Probable (n=68)
|
|---|
|
Male
|
112 (62.6%)
|
149 (78.0%)
|
0.001
|
97 (78.9%)
|
52 (76.5%)
|
0.702
|
0.003
|
0.039
|
| |
P50 (P25-P75)e
|
P50 (P25-P75)
| |
P50 (P25-P75)
|
P50 (P25-P75)
| | | |
|
Age
|
54 (45-64)
|
53 (46-61)
|
0.661
|
52 (46-60)
|
55 (45-64)
|
0.373
|
0.474
|
0.869
|
|
Serum RPR titer
|
1:1 (Negative-1:2)
|
1:16 (1:4-1:64)
|
<0.001
|
1:32 (1:16-1:64)
|
1:2 (1:1-1:8)
|
<0.001
|
<0.001
|
<0.001
|
|
Serum TPPA titer
|
1:640 (1:320-1:1280)
|
1:10240 (1:2560-1:20480)
|
<0.001
|
1:20480 (1:10240-1:20480)
|
1:2560 (1:1280-1:5120)
|
<0.001
|
<0.001
|
<0.001
|
|
CSF RPR titer
|
Negative
|
1:2 (Negative-1:4)
|
<0.001
|
1:4 (1:2-1:8)
|
Negative
|
<0.001
|
<0.001
|
1.0
|
|
CSF TPPA titer
|
Negative
|
1:1280 (1:160-1:5120)
|
<0.001
|
1:5120 (1:1280-1:10240)
|
1:80 (1:80-1:640)
|
<0.001
|
<0.001
|
<0.001
|
|
CSF leukocyte (cells/μL)
|
4 (2-7)
|
15 (6-48)
|
<0.001
|
29 (12-59)
|
6 (2-13)
|
<0.001
|
<0.001
|
0.015
|
|
CSF protein (mg/L)
|
390.9 (289.9-540.0)
|
606.0 (418.6-884.3)
|
<0.001
|
733.9 (502.0-1025.0)
|
443.1 (325.8-607.2)
|
<0.001
|
<0.001
|
0.183
|
|
CSF albumin (mg/L)
|
249.0 (173.7-361.9)
|
296.4 (220.0-456.2)
|
0.003
|
296.4 (243.0-500.6)
|
297.0 (182.7-446.2)
|
0.218
|
0.001
|
0.204
|
|
CSF glucose (mmol/L)
|
3.70 (3.40-4.20)
|
3.54 (3.21-4.19)
|
0.037
|
3.48 (3.12-4.08)
|
3.74 (3.25-4.20)
|
0.030
|
0.003
|
0.913
|
|
CSF chloride (mmol/L)
|
124.3 (121.9-126.4)
|
124.4 (121.5-126.3)
|
0.696
|
124.8 (121.5-126.5)
|
123.9 (121.6-125.9)
|
0.303
|
0.902
|
0.330
|
|
CSF lactate (mmol/L)
|
1.76 (1.57-2.02)
|
1.89 (1.67-2.17)
|
0.043
|
1.90 (1.73-2.30)
|
1.83 (1.66-2.06)
|
0.160
|
0.018
|
0.516
|
|
CSF lactate dehydrogenase (U/L)
|
20.2 (16.7-27.7)
|
20.2 (16.0-26.5)
|
0.696
|
19.5 (16.0-23.6)
|
22.2 (17.8-34.1)
|
0.032
|
0.131
|
0.184
|
|
Intracranial pressure (mmH2O)
|
135 (110-160)
|
140 (110-160)
|
0.604
|
140 (110-160)
|
140 (100-160)
|
0.882
|
0.656
|
0.692
|
-
N-NS syphilis/non-neurosyphilis, S-NS symptomatic neurosyphilis, RPR rapid plasma reagin, TPPA T. pallidum particle agglutination, CSF cerebrospinal fluid, P
a Comparison between the S-NS group and the N-NS group, P
b Comparison between the confirmed neurosyphilis subgroup and the probable neurosyphilis subgroup, P
c Comparison between the confirmed neurosyphilis subgroup and the N-NS, P
d Comparison between the probable neurosyphilis subgroup and the N-NS
-
eData with skewed distribution was described using median (interquartile range)
