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Table 2 Serum RPR and serum TPPA reactivity associated with S-NS

From: Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study

  S-NS
n (%)
N-NS
n (%)
OR P   S-NS
n (%)
N-NS
n (%)
OR P
Serum RPR titers      Serum RPR titers     
 Negative 6(3.2) 68(38.2) 1.0 (Ref.)       
 1:1 17(9.0) 38(21.3) 5.070 0.002 ≥1:1 (vs <1:1) 182(96.8) 110(61.8) 18.752 <0.001
 1:2 21(11.2) 36(20.2) 6.611 <0.001 ≥1:2 (vs <1:2) 165(87.8) 72(40.4) 10.562 <0.001
 1:4 18(9.6) 13(7.3) 15.692 <0.001 ≥1:4 (vs <1:4) 144(76.6) 36(20.2) 12.909 <0.001
 1:8 16(8.5) 8(4.5) 22.667 <0.001 ≥1:8 (vs <1:8) 126(67.0) 23(12.9) 13.696 <0.001
 1:16 24(12.8) 5(2.8) 54.400 <0.001 ≥1:16 (vs <1:16) 110(58.5) 15(8.4) 15.325 <0.001
 1:32 26(13.8) 7(3.9) 42.095 <0.001 ≥1:32 (vs <1:32) 86(45.7) 10(5.6) 14.165 <0.001
 1:64 35(18.6) 1(0.6) 396.667 <0.001 ≥1:64 (vs <1:64) 60(31.9) 3(1.7) 27.344 <0.001
 ≥1:128 25(13.3) 2(1.1) 141.667 <0.001 ≥1:128 (vs <1:128) 25(13.3) 2(1.1) 13.497 <0.001
Serum TPPA titers      Serum TPPA titers     
 ≤1:160a 2(1.1) 40(22.5) 1.0 (Ref.)       
 1:320 5(2.7) 41(23.0) 2.439 0.303 ≥1:320 (vs <1:320) 186(98.9) 138(77.5) 26.957 <0.001
 1:640 7(3.7) 32(18.0) 4.375 0.078 ≥1:640 (vs <1:640) 181(96.3) 97(54.5) 21.592 <0.001
 1:1280 18(9.6) 34(19.1) 10.588 0.003 ≥1:1280 (vs <1:1280) 174(92.6) 65(36.5) 21.607 <0.001
 1:2560 23(12.2) 12(6.7) 38.333 <0.001 ≥1:2560 (vs <1:2560) 156(83.0) 31(17.4) 23.117 <0.001
 1:5120 21(11.2) 11(6.2) 38.182 <0.001 ≥1:5120 (vs <1:5120) 133(70.7) 19(10.7) 20.236 <0.001
 1:10240 29(15.4) 5(2.8) 116.000 <0.001 ≥1:10240 (vs <1:10240) 112(59.6) 8(4.5) 31.316 <0.001
 ≥1:20480 83(44.1) 3(1.7) 553.333 <0.001 ≥1:20480 (vs <1:20480) 83(44.1) 3(1.7) 46.111 <0.001
  1. S-NS symptomatic neurosyphilis, N-NS syphilis/non-neurosyphilis, RPR rapid plasma reagin, TPPA T. pallidum particle agglutination, OR odds ratio, Ref., reference
  2. aThis group included two S-NS patients and 21 N-NS patients with serum TPPA titers of 1:160 and 19 N-NS patients with serum TPPA titers of 1:80
  3. P for trend <0.001
  4. P for trend <0.001