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Table 4 Comparison between S-NS and N-NS in comorbidities and serum biochemical parameters

From: Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study

  S-NS (n=191)
n (%)
N-NS (n=179)
n (%)
P a S-NS P b P c
Confirmed (n=123) n (%) Probable (n=68) n(%)
Comorbidities
 Other CNS infectionsd 3 (1.6) 0 0.249 3 (2.4) 0 0.067 n.a.
 Brain injury 7 (3.7) 5 (2.8) 0.636 6 (4.9) 1 (1.5) 0.364 1.0
 Brain tumors 2 (1.0) 3 (1.7) 0.676 1 (0.8) 1 (1.5) 0.648 1.0
 Psychiatric disorders 12 (6.3) 2 (1.1) 0.009 7 (5.7) 5 (7.4) 0.034 0.018
 History of ischemic stroke 36 (18.8) 24 (13.4) 0.156 19 (15.4) 17 (25.0) 0.618 0.029
 History of hemorrhagic stroke 0 4 (2.2) 0.054 0 0 0.148 0.578
 Hypertension 83 (43.5) 85 (47.5) 0.436 47 (38.2) 36 (52.9) 0.110 0.444
 Heart diseasese 32 (16.8) 33 (18.4) 0.671 19 (15.4) 13 (19.1) 0.499 0.902
 Diabetes mellitus 59 (30.9) 40 (22.3) 0.064 37 (30.1) 22 (32.4) 0.130 0.105
 Chronic alcoholism 5 (2.6) 1 (0.6) 0.216 5 (4.1) 0 0.043 1.0
Serum biochemical parameters
 Elevated FPG (≥7.0 mmol/L) 38 (19.9) 24 (13.4) 0.095 30 (24.4) 8 (11.8) 0.014 0.731
 Elevated HbA1c (≥6.5%) 36 (28.3) 29 (25.4) 0.612 22 (27.2) 14 (30.4) 0.787 0.519
 Elevated CKf(male ≥308, female ≥192 U/L) 30 (16.9) 11 (6.6) 0.003 19 (17.0) 11 (16.9) 0.006 0.017
 Elevated HCYg 42 (32.1) 22 (18.3) 0.013 25 (32.9) 17 (30.9) 0.020 0.063
 Elevated TG (≥1.70 mmol/L) 41 (22.3) 41 (24.6) 0.616 22 (18.6) 19 (28.8) 0.237 0.505
 Elevated CHOL (≥6.22 mmol/L) 8 (4.3) 11 (6.6) 0.355 3 (2.5) 5 (7.6) 0.120 0.778
 Elevated ALT (male ≥50, female ≥40 U/L) 14 (7.3) 16 (9.0) 0.560 11 (8.9) 3 (4.4) 0.989 0.229
 Elevated AST (male ≥40, female ≥35 U/L) 21 (11.1) 15 (8.5) 0.407 16 (13.0) 5 (7.5) 0.205 0.797
 Elevated TBIL (≥17.1 μmol/L) 34 (18.1) 26 (15.0) 0.436 23 (18.9) 11 (16.7) 0.385 0.754
 Elevated BUN (≥8.2 mmol/L) 8 (4.2) 12 (6.7) 0.285 6 (4.9) 2 (2.9) 0.510 0.361
 Elevated sCr (male ≥115, female ≥97 μmol/L) 6 (3.1) 12 (6.7) 0.111 2 (1.6) 4 (5.9) 0.039 1.0
  1. S-NS symptomatic neurosyphilis, N-NS syphilis/non-neurosyphilis, CNS central nervous system, FPG fasting plasma glucose, HbA1c glycated hemoglobin (A1c), CK creatine kinase, HCY homocysteine, TG triglyceride, CHOL cholesterol, ALT alanine transaminase, AST aspartate transaminase, TBIL total bilirubin, BUN blood urea nitrogen, sCr serum creatinine
  2. P a Comparison between the S-NS group and the N-NS group, P b Comparison between the confirmed neurosyphilis subgroup and the N-NS group, P c Comparison between the probable neurosyphilis subgroup and the N-NS group
  3. dTwo patients had viral encephalitis and one patient had viral meningitis before being diagnosed with S-NS
  4. eHeart diseases includes coronary heart disease, hypertensive heart disease, valvular heart disease and cardiac arrhythmia
  5. fOne patient with acute myocardial infarction was excluded
  6. gHomocysteine ≥15 μmol/L in male or ≥12 μmol/L in female in <60 age group, or ≥20 μmol/L in ≥60 age group