Skip to main content

Table 5 Odds ratios of S-NS (with 95% confidence intervals) according to gender, syphilitic serological characteristics and serum creatine kinase levels

From: Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study

 

Serum RPR titer <1:4

Serum RPR titer ≥1:4

Serum TPPA titer <1:2560

Serum TPPA titer ≥1:2560

Serum TPPA titer <1:2560

Serum TPPA titer ≥1:2560

Normal CK

Elevated CK

Normal CK

Elevated CK

Normal CK

Elevated CK

Normal CK

Elevated CK

S-NS

 Female

1.0 (Ref.)

n.a.a

6.500 * (1.273-33.201)

n.a.b

2.437 (0.502-11.845)

n.a.c

20.583 * (5.853-72.380)

n.a.d

 Male

1.264 (0.450-3.550)

3.900 (0.734-20.709)

9.286 * (2.549-33.832)

9.750 * (1.340-70.966)

4.643 * (1.107-19.475)

6.500 (0.357-118.370)

53.300 * (18.073-157.194)

n.a.d

Confirmed neurosyphilis

 Female

1.0 (Ref.)

n.a.a

9.750 (0.507-187.526)

n.a.b

4.875 (0.275-86.351)

n.a.c

104.000 * (11.575-934.402)

n.a.d

 Male

1.083 (0.095-12.329)

n.a.e

n.a.e

39.000 * (2.397-634.654)

11.143 (0.886-140.119)

n.a.e

265.200 * (32.704-2150.534)

n.a.d

Probable neurosyphilis

 Female

1.0 (Ref.)

n.a.a

5.850 * (1.004-34.100)

n.a.b

1.950 (0.320-11.888)

n.a.c

3.900 (0.734-20.709)

n.a.d

 Male

1.300 (0.427-3.959)

4.680 (0.849-25.811)

11.143 * (2.913-42.620)

3.900 (0.297-51.196)

3.343 (0.647-17.267)

7.800 (0.419-145.200)

10.920 * (3.176-37.549)

n.a.d

  1. S-NS symptomatic neurosyphilis, N-NS syphilis/non-neurosyphilis, RPR rapid plasma reagin, TPPA T. pallidum particle agglutination, CK creatine kinase, OR odds ratio, Ref. reference, n.a. not applicable
  2. * P<0.05
  3. aNo female patient with serum RPR titer <1:4, TPPA titer <1:2560 and elevated CK was in the S-NS group; the OR of S-NS was not applicable
  4. bNo female patient with serum RPR titer <1:4, TPPA titer ≥1:2560 and elevated CK was in the N-NS group; the OR of S-NS was not applicable
  5. cNo female patient with serum RPR titer ≥1:4, TPPA titer <1:2560 and elevated CK was in both groups; the OR of S-NS was not applicable
  6. dIn both male and female patients, there was no one with serum RPR titer ≥1:4, TPPA titer ≥1:2560 and elevated CK in the N-NS group; the OR of S-NS was not applicable
  7. eNo male patient with serum RPR titer <1:4, TPPA titer <1:2560 and elevated CK, or serum RPR titer <1:4, TPPA titer ≥1:2560 and normal CK, or serum RPR titer ≥1:4, TPPA titer <1:2560 and elevated CK was in the confirmed neurosyphilis subgroup; the OR of confirmed neurosyphilis was not applicable