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Table 5 Odds ratios of S-NS (with 95% confidence intervals) according to gender, syphilitic serological characteristics and serum creatine kinase levels

From: Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study

  Serum RPR titer <1:4 Serum RPR titer ≥1:4
Serum TPPA titer <1:2560 Serum TPPA titer ≥1:2560 Serum TPPA titer <1:2560 Serum TPPA titer ≥1:2560
Normal CK Elevated CK Normal CK Elevated CK Normal CK Elevated CK Normal CK Elevated CK
S-NS
 Female 1.0 (Ref.) n.a.a 6.500 * (1.273-33.201) n.a.b 2.437 (0.502-11.845) n.a.c 20.583 * (5.853-72.380) n.a.d
 Male 1.264 (0.450-3.550) 3.900 (0.734-20.709) 9.286 * (2.549-33.832) 9.750 * (1.340-70.966) 4.643 * (1.107-19.475) 6.500 (0.357-118.370) 53.300 * (18.073-157.194) n.a.d
Confirmed neurosyphilis
 Female 1.0 (Ref.) n.a.a 9.750 (0.507-187.526) n.a.b 4.875 (0.275-86.351) n.a.c 104.000 * (11.575-934.402) n.a.d
 Male 1.083 (0.095-12.329) n.a.e n.a.e 39.000 * (2.397-634.654) 11.143 (0.886-140.119) n.a.e 265.200 * (32.704-2150.534) n.a.d
Probable neurosyphilis
 Female 1.0 (Ref.) n.a.a 5.850 * (1.004-34.100) n.a.b 1.950 (0.320-11.888) n.a.c 3.900 (0.734-20.709) n.a.d
 Male 1.300 (0.427-3.959) 4.680 (0.849-25.811) 11.143 * (2.913-42.620) 3.900 (0.297-51.196) 3.343 (0.647-17.267) 7.800 (0.419-145.200) 10.920 * (3.176-37.549) n.a.d
  1. S-NS symptomatic neurosyphilis, N-NS syphilis/non-neurosyphilis, RPR rapid plasma reagin, TPPA T. pallidum particle agglutination, CK creatine kinase, OR odds ratio, Ref. reference, n.a. not applicable
  2. * P<0.05
  3. aNo female patient with serum RPR titer <1:4, TPPA titer <1:2560 and elevated CK was in the S-NS group; the OR of S-NS was not applicable
  4. bNo female patient with serum RPR titer <1:4, TPPA titer ≥1:2560 and elevated CK was in the N-NS group; the OR of S-NS was not applicable
  5. cNo female patient with serum RPR titer ≥1:4, TPPA titer <1:2560 and elevated CK was in both groups; the OR of S-NS was not applicable
  6. dIn both male and female patients, there was no one with serum RPR titer ≥1:4, TPPA titer ≥1:2560 and elevated CK in the N-NS group; the OR of S-NS was not applicable
  7. eNo male patient with serum RPR titer <1:4, TPPA titer <1:2560 and elevated CK, or serum RPR titer <1:4, TPPA titer ≥1:2560 and normal CK, or serum RPR titer ≥1:4, TPPA titer <1:2560 and elevated CK was in the confirmed neurosyphilis subgroup; the OR of confirmed neurosyphilis was not applicable