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Table 4 Mutations associated with RMP and INH drug resistant TB among concordant Resistant result with Genotype MTBDRplus VER 2.0 and MGIT DST

From: Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples

RMP resistance

INH resistance

 

rpoB gene

KatG gene

inhA gene

WT1–8 missing

Mutant

WT missing

Mutant

WT1–2 missing

Mutant

Frequency

530–533 (WT8)

S531L

315

S315TL

-

-

23

530–533 (WT8)

S531L

315

-

-

-

3

526–529 (WT7)

H526Y

315

S315TL

-

-

1

530–533 (WT8)

S531L

315

-

-

-

1

526–529 (WT7)

H526Y

315

S315TL

-15,-16 (WT1)

C15T

1

-8 (WT2)

A16G

a510–513 (WT2)

-

    

1

516–519 (WT4)

      

522–526 (WT6)

      

526–529 (WT7)

      

a505–509 (WT1)

-

    

1

513–517 (WT3)

      

526–529 (WT7)

      

530–533 (WT8)

      
  

b315

S315TL

-

-

3

  

b315

-

-15,-16 (WT1)

-

1

  1. aMutations associated with RMP mono resistance, bMutations associated with INH mono resistance
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BMC Infectious Diseases

ISSN: 1471-2334

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