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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Enhanced chlorhexidine skin penetration with 1,8-cineole

Fig. 1

Concentration of CHG in skin following exposure to 2% CHG/70% IPA with or without 2% (v/v) 1,8-cineole. Penetration profile showing the concentration of CHG in excised human skin (0-2000 μm depth) after exposure to 2% (w/v) CHG in 70% (v/v) IPA with and without 2% (v/v) 1,8-cineole (mean ± SEM). Background levels of CHG derived from preoperative skin antisepsis, without any further CHG added are also presented. The purple line represents the MIC value of CHG against MRSA (N315) in a biofilm [9]. The assumption that 1 g of skin is equal to 1 mL was made. The concentration of CHG in the skin was significantly higher in the CHG/IPA with 1,8-cineole group compared to the CHG/IPA alone (P = 0.042). The size of the effect did not vary according to the depth of penetration into the skin (P = 0.311), indicating that the concentration of CHG was higher at all depths with the addition of 1,8-cineole

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