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Table 3 Distribution of rs12998782, rs17009726, rs1194182, rs3211956 and rs10499859 alleles, and genotype frequencies in PTB patients and healthy controls

From: Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population

 

Patients

Controls

OR

χ2

95% CI

P

(n = 202)

(n = 216)

MARCO

rs12998782

Genotype

 CC

117 (57.9%)

131(60.6%)

Reference

 

Reference

 

 CT

66 (32.7%)

77 (35.7%)

0.974

0.038

0.750–1.266

0.845

 TT

19 (9.4%)

8 (3.7%)

2.427

5.24

1.100–5.357

0.022*

 CC + CT

183 (90.6%)

208(96.3%)

Reference

 

Reference

 

 TT

19 (9.4%)

8 (3.7%)

2.54

5.617

1.137–5.672

0.018*

Allele

 C

300 (74.3%)

339(78.5%)

Reference

 

Reference

 

 T

104 (25.7%)

93 (21.5%)

1.196

2.059

0.936–1.527

0.151

rs17009726

Genotype

 AA

156 (77.2%)

163(75.5%)

Reference

 

Reference

 

 AG

46 (22.8%)

53 (24.5%)

0.928

0.18

0.657–1.311

0.671

Allele

 A

358 (88.6%)

379(87.7%)

Reference

 

Reference

 

 G

46 (11.4%)

53 (12.3%)

0.928

0.156

0.640–1.345

0.693

CD36

rs1194182

Genotype

 CC

45 (22.3%)

51 (23.6%)

Reference

 

Reference

 

 CG

126 (62.4%)

99 (45.8%)

1.116

2.251

0.965–1.291

0.134

 GG

31 (15.3%)

66 (30.6%)

0.723

4.497

0.528–0.990

0.034*

 CC + CG

171 (84.7%)

150(69.4%)

Reference

 

Reference

 

 GG

31 (15.3%)

66 (30.6%)

0.502

13.549

0.343–0.735

<0.01*

Allele

 C

216 (53.5%)

201(46.5%)

Reference

 

Reference

 

 G

188 (46.5%)

231(54.5%)

0.87

4.019

0.759–0.998

0.045*

rs3211956

Genotype

 GG

8 (4.0%)

9(4.1%)

Reference

 

Reference

 

 GT

58 (28.7%)

56 (25.9%)

1.02

0.086

0.894–1.164

0.769

 TT

136(67.3%)

151(70.0%)

1.001

0.001

0.947–1.057

0.979

Allele

 G

74 (18.3%)

74 (17.1%)

Reference

 

Reference

 

 T

330 (81.7%)

358(82.9%)

0.986

0.202

0.925–1.050

0.653

rs10499859

Genotype

 AA

79 (39.1%)

57 (26.4%)

Reference

 

Reference

 

 AG

109 (54.0%)

102(47.2%)

0.904

1.377

0.764–1.069

0.241

 GG

14 (6.9%)

57 (26.4%)

0.301

27.756

0.180–0.505

<0.001*

 AA + AG

188 (93.1%)

159(73.6%)

Reference

 

Reference

 

 GG

14 (6.9%)

57 (26.4%)

0.263

28.028

0.151–0.456

<0.001*

Allele

 A

267 (66.1%)

216(50.0%)

Reference

 

Reference

 

 G

137 (33.9%)

216(50.0%)

0.678

22.152

0.575–0.800

<0.001*

  1. OR odds ratio, 95% CI 95% confidence interval
  2. *P< 0.05 indicates statistical significance