Evaluation of creatine kinase and liver enzymes in identification of severe dengue

BMC Infectious Diseases

Table 2 Laboratory parameters of 365 patients hospitalized with dengue

	All		Severe Dengue		Non-severe Dengue		p-value
	n	No. (% or IQR)	n	No. (% or IQR)	n	No. (% or IQR)	p-value
Duration of febrile phase (d)	360	4.8 (3.8 - 5.8)	21	5 (4.1 - 7.3)	339	4.8 (3.8 - 5.8)	0.170^b
Phase at admission, febrile	360	230 (63.90%)	21	16 (76.20%)	339	214 (63.10%)	0.250^a
Day of presentation (d)	361	4.3 (3.2 - 5.3)	22	4.2 (3.1 - 5.1)	339	4.3 (3.2 - 5.4)	0.570^b
NS1 Ag	356	288 (80.90%)	22	20 (90.90%)	334	268 (80.20%)	0.270^a
High-titre IgG	360	160 (44.40%)	22	11 (50.00%)	338	149 (44.10%)	0.660^a
Admission Hct, median (IQR), %	365	42 (39 - 46)	22	41 (37 - 43)	343	42 (39 - 46)	0.160^b
Admission CK, median (IQR), IU/L	354	208 (103 - 409)	19	212 (116 - 300)	335	207 (103 - 424)	0.760^b
Admission AST, median (IQR), IU/L	364	79 (47 - 135)	22	231 (97 - 564)	342	75 (47 - 128)	< 0.001^b
Admission ALT, median (IQR), IU/L	365	51 (29 - 100)	22	122 (49 - 230)	343	49 (28 - 91)	0.003^b
Nadir WBC, median (IQR), ×10³/μL	364	2.5 (1.9 - 3.6)	22	2.8 (2 - 3.8)	342	2.5 (1.9 - 3.6)	0.540^b
Nadir Platelet, median (IQR), ×10³/μL	364	41 (21 - 67)	22	27 (10 - 49)	342	42 (22 - 67)	0.020^b
Nadir Serum Albumin, median (IQR), g/L	326	32 (30 - 36)	21	27 (23 - 29)	305	33 (30 - 36)	< 0.001^b
Peak CK, median (IQR), IU/L	103	429 (199 - 1044)	10	404 (171 - 766)	93	431 (206 - 1118)	0.430^b
Peak AST, median (IQR), IU/L	338	123 (74 - 243)	21	585 (144 - 1098)	37	116 (73 - 223)	< 0.001^b
Peak ALT, median (IQR), IU/L	340	86 (41 - 175)	22	225 (107 - 403)	318	81 (39 - 162)	< 0.001^b

^a Fisher’s exact test or Chi square test, as appropriate
^b Mann-Whitney U test
^c Chi-square for trend
IQR interquartile range, CK creatine kinase, AST aspartate transaminase, ALT alanine transaminase, WBC white blood cell count, AKI acute kidney injury

ISSN: 1471-2334