Fig. 7From: Magnetic hyperthermia enhance the treatment efficacy of peri-implant osteomyelitisHistological and scanning electron microscope examination of different treatment modalities for osteomyelitis rats after 40Â days infection. After inoculation of Staphylococcus aureus, tissue necrosis with active inflammation and even biofilm formation was clearly demonstrated in all groups; while, the biofilm formation were found both the at the surface of the inserted pin and the inner surface of bony trabeculae. Group I: osteomyelitis positive control without treatment; Group II: osteomyelitis treated with intramuscular injection of vancomycin [VC (i.m.)]; Group III: osteomyelitis treated with both intramuscular and femur cavity injection of vancomycin [VC (i.m.)Â +Â VC (f.c)]; Group IV: osteomyelitis treated with both intramuscular injection of vancomycin and magnetic particles [VC(i.m.)Â +Â M]; Group V: osteomyelitis treated with intramuscular injection of vancomycin and magnetic particles hyperthermia [VC(i.m.)Â +Â MÂ +Â IOHA]. Animals from each group were sacrificed by overdose of pentobarbital at 40Â days after surgery. *(red): biofilm-like ECM; **(black): necrosis with inflammation; ***(green): inflammationBack to article page