From: Procalcitonin-guided antibiotic therapy in critically ill adults: a meta-analysis
Study (year) | Primary endpoints | Second endpoints | |||||
---|---|---|---|---|---|---|---|
28-day mortality | duration of antibiotic therap by for the first episode of infectiona | length of hospitalizationa | mortality in hospitalization | total duration of antibiotic therapy a | length of ICU stay a | Recurrences | |
Svoboda (2007) [33] | 10/13 | NA | NA | NA | NA | 16.1 (6.9) /19.4 (8.9) | NA |
Nobre (2008) [32] | 8/8 | 6.0 (7.8) /9.5 (7.8) | 17.0 (23.3) /23.5 (9.8) | 9/9/ | 8.0 (5.8) /14.0 (8.3) | 4.0 (5.0) /7.0 (22.5) | 1/1/ |
Hochreiter (2009) [31] | NA | 5.9 (1.7) /7.9 (0.5) | NA | 15/14 | 5.9 (1.7) /7.9 (0.5) | 15.5 (12.5) /17.7 (10.1) | NA |
Schroeder (2009) [30] | NA | 6.6 (1.1) /8.3 (0.7) | NA | 3/3 | 6.6 (1.1) /8.3 (0.8) | 16.4 (8.3) /16.7 (5.6) | NA |
Stolz (2009) [29] | 8/12 | 3.0 (2.0) /5.0 (4.1) | 26.0 (10.4) /26.0 (4.1) | 10/14 | 10.0 (2.5) /15.0 (3.3) | NA | 6/11 |
Bouadma (2010) [28] | 65/64 | 6.1 (6.0) /9.9 (7.1) | 26.1 (19.3) /26.4 (18.3) | NA | 10.3 (7.7) /13.3 (7.6) | 15.9 (16.1) /14.4 (4.1) | 20/16 |
Layios (2012) [26] | 56/53 | NA | NA | NA | NA | 7.0 (8.9) /7.0 (10.4) | NA |
Jensen (2011) [27] | 190/191 | NA | NA | NA | NA | 6.0 (6.7) /5.0 (5.9) | NA |
Liu (2013) [23] | 6/5 | 8.1 (0.3) /9.3 (0.3) | 27.0 (4.9) /32.0 (5.4) | NA | 8.1 (0.3) /9.3 (0.3) | 12.0 (2.9) /14.0 (2.7) | 3/1 |
Annane (2013) [25] | NA | NA | 27.0 (29.6) /33.0 (43.0) | 7/10 | NA | 22.0 (25.2) /23.0 (37.0) | NA |
Deliberato (2013) [24] | NA | NA | 11.0 (11) /11.0 (56.5) | 2/4 | NA | 3.5 (14.0) /3.0 (6.8) | 2/1 |
Shehabi (2014) [22] | 21/15 | NA | 15.0 (14.8) /17.0 (16.3) | 30/26 | NA | 6.0 (4.8) /6.0 (4.4) | 6/12 |
Najafi (2015) [21] | NA | NA | 20.0 (9.0) /22.0 (14.8) | 5/4 | NA | 4.0 (4.5) /6.0 (6.5) | NA |
Jong (2016) [18] | 149/196 | NA | 22.0 (19.3) /22.0 (20.7) | NA | NA | 8.5 (8.9) /9.0 (9.6) | 38/23 |
Bloos (2016) [20] | 77/60 | 7.0 (6.7) /7.0 (7.4) | 29.0 (23.7) /29.0 (24.4) | NA | NA | 12.0 (14.1) /12.0 (11.1) | NA |