Demographic and clinical characteristic of HIV patients, N = 10,671 (100%) | HIV-infected patients who remained free of TB, N = 10,532 (98.7%) | HIV-infected patients developing TB, N = 139 (1.3%) | P value |
---|---|---|---|
Female sex | 2388 (22.5%) | 45 (31.5%) | 0.01b |
Age at time of cART initiation | |||
Median (IQR), years | 38.0 (31 – 45) | 36.5 (31 – 45) | 0.8c |
Geographical origin | |||
Germany | 7289 (70.1%) | 60 (42.9%) | <0.001b |
Sub-Saharan Africa | 1344 (12.9%) | 50 (35.7%) | |
South−/Southeast Asia | 273 (2.7%) | 10 (7.1%) | |
Others | 1486 (14.3%) | 20 (14.3%) | |
HIV-transmission routes | |||
MSM | 5377 (56.9%) | 49 (36.6%) | <0.001b |
IDUs | 886 (9.4%) | 8 (6.0%) | |
Others | 3186 (33.7%) | 77 (57.4%) | |
Calendar year of cART initiation | <0.001b | ||
1999-2002 | 2524 (23.9%) | 56 (24.2%) | |
2003-2008 | 4531 (43.1%) | 58 (43.0%) | |
2009-2013 | 3477 (33.0%) | 25 (32.8%) | |
Baseline CD4+ counta | |||
Median (IQR), cells per μl | 285 (173 – 413) | 168 (80 - 326) | 0.1c |
Baseline CD8+ counta | |||
Median (IQR), cells per μl | 900 (602 – 1297) | 846 (609 – 1364) | 0.8c |
Baseline CD4:CD8 ratioa | |||
Median (IQR) | 0.3 (0.2 – 0.5) | 0.2 (0.1 – 0.3) | 0.3c |
Baseline viral loada | |||
Median (IQR), log10 copies per ml | 4.6 (3.6 – 5.2) | 4.9 (3.7 – 5.1) | 0.06c |