Table 1 Specification of population, intervention, comparison and outcomes (PICO)
| Â | Inclusion criteria | Exclusion criteria |
|---|---|---|
Population | • Adult patients (aged >18 years) • Chronically infected with HCV GT3 | • Healthy subjects • Patients without chronic HCV infection • Non-GT3 infection or lack of GT3-specific stratification • Studies in animals • In vitro studies |
Intervention | • Any antiviral agent against HCV in at least one arm | • Non-antiviral therapy |
Comparison | • Randomised controlled trials • Non-randomised controlled trials • Observational studies (including reports of Registry audits) | • Pharmacokinetics studies • Cost-effectiveness studies • Clinical trial registry entry only • Reviews, editorial, letter or comment • Case control studies • Cohort studies |
Outcome | • SVR4 • SVR12 • SVR24 • Unspecified SVR | • If SVR is not reported |
Language restrictions | • English language only | • Studies published in language other than English are excluded |
Date range | • February 2011 to May 2016 | • Studies outside this timeframe are excluded |