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Table 2 Clinical data of pandemic and postpandemic patients

From: ICU-treated influenza A(H1N1) pdm09 infections more severe post pandemic than during 2009 pandemic: a retrospective analysis

Variables

2009–2010 Pandemic (n = 16)

2012–2016 Postpandemic (n = 60)

p value

Delay from symptoms to hospital admission, hours

108.0 (48–168)

72 (24–168)

0.37

Delay from hospital admission to ICU admission, days

1.9 (1.12–4.78)

1.04 (0.07–2.18)

0.25

Principal symptoms

 fever

10 (66.7)

43(71.7)

0.06

 dyspnea

10 (62.5)

52 (86.7)

0.037

 cough

11 (68.8)

28 (46.7)

0.16

 gastrointestinal

5 (31.3)

13 (21.7)

0.51

 neurological

1 (6.3)

15 (25)

0.17

PaO2/FiO2, kPa

33.4 (16.5–40.6)

26.3 (15.0–42.6)

0.41

Pneumonia on chest x-ray

11 (68.8)

53 (88.3)

0.11

 Bilateral opacities

11 (100.0)

49 (92.5)

0.16

ARDS

  

0.69

 No

5 (31.3)

17 (28.3)

 

 Mild

2 (12.5)

3 (5.0)

 

 Moderate

3 (18.8)

14 (23.3)

 

 Severe

6 (37.5)

26 (43.3)

 

Presence of bacteremia on admission

0

5 (10)

0.33

Mixed bacterial infection

7 (43.8)

9 (15)

0.033

Antiviral treatment on ICU admission

13 (81.3)

45 (75)

0.75

Bacterial antibiotics

15 (93.8)

48 (82)

0.48

  1. ARDS acute respiratory distress syndrome, ICU intensive care unit
  2. PaO2/FiO2 ratio is the ratio of arterial oxygen partial pressure to fractional inspired oxygen
  3. Values are presented as median (25th–75th percentile) or as number (percentage) of patients