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Table 1 Patient characteristics and bivariate analysis of the costs of the first 12 months after allogeneic stem cell transplantation

From: Economic burden of preemptive treatment of CMV infection after allogeneic stem cell transplantation: a retrospective study of 208 consecutive patients

Variable

Characteristics

Cost after 12 months (€)

N

Mean (SD)

P-value

Age (years)

< 30

31

103,146 (44,270)

0.6285a

30 to 50

65

107,689 (35,434)

> 50

112

102,125 (36,422)

Sex

F

87

99,375 (33,651)

0.1282b

M

121

107,353 (39,485)

Underlying disease

Acute leukemia and myelodysplastic syndrome

143

100,960 (31,157)

0.2259a

Lymphoproliferative disorder

46

111,367 (48,575)

Myeloproliferative disorder

12

116,491 (56,018)

Other

7

96,756 (22,709)

Donor type

HLA identical sibling

83

103,795 (41,940)

0.8294a

Unrelated donor

107

104,998 (33,467)

Cord blood unit

18

99,200 (37,742)

D/R match

HLA identical sibling

83

103,795 (41,940)

0.8986a

Unrelated donor 10/10 and cord blood unit 6/6

63

102,644 (32,594)

Unrelated donor 9/10 and cord blood unit 4/6 or 5/6

62

105,706 (35,598)

Stem cell source

Bone marrow

50

99,679 (39,183)

0.7950a

Peripheral blood stem cell

140

106,184 (36,604)

Cord blood unit

18

99,200 (37,742)

Conditioning regimen

Reduced intensity

92

108,178 (31,779)

0.3566a

Mini

61

101,129 (42,830)

Myeloablative

55

100,256 (39,172)

Recipient CMV serology

R+

130

103,494 (34,279)

0.7950b

R-

78

104,886 (42,030)

Number of CMV episodes

0

138

99,793 (39,654)

0.0214a

1

44

104,815 (24,271)

≥2

26

125,080 (36,290)

Acute graft-versus-host disease

0 and 1

112

96,278 (37,441)

0.0011a

2 to 4

96

113,043 (35,180)

Chronic graft-versus-host disease

No

140

101,858 (33,633)

0.2320b

Yes

68

108,458 (43,789)

Alive at the end of the mentioned period

No

80

109,067 (29,356)

0.1227b

Yes

128

100,859 (41,270)

First CMV infection

≤100 days

53

109,015 (30,231)

0.1841 b

>100 days

18

119,834 (32,142)

  1. aAnova test; b Student test