Table 6 Risk factors associated with 14-day inpatient mortality in children with BSI
From: Bloodstream infections at a tertiary level paediatric hospital in South Africa
Factor | Univariate HR (95% CI) | P value | Adjusted HR (95%CI) | P value |
|---|---|---|---|---|
Age | N = 693 | |||
0–28 days | 0.9 (0.4–2) | 0.834 | 1 | |
1 - < 2 months | 2.2 (1.1–4.6) | 0.035 | 1 | |
2 - < 12 months | 1.2 (0.8–2) | 0.376 | 1 | |
12 months – 5 years | 0.7 (0.4–1.2) | 0.219 | 1 | |
> 5 years | 1 | 1 | ||
Nutritional status | N = 693 | |||
Severe underweight for age | 2.4 (1.5–3.9) | 0.0001 | 2.0 (1.2–3.3) | 0.007 |
Moderate underweight for age | 1.1 (0.6–2) | 0.851 | 1 | |
Mild-normal weight for age | 1 | 1 | ||
Weight not recorded | 2.4 (1–5.9) | 0.060 | 4.9 (1.2–20.8) | 0.029 |
Haemoglobin | N = 693 | |||
Severe anaemia (< 7 g/dL) | 3.3 (1.7–6.4) | 0.001 | 2.7 (1.3–5.6) | 0.006 |
Mild anaemia (7–11 g/dL) | 1 (0.6–1.7) | 0.909 | 1 | |
No anaemia (≥ 11 g/dL) | 1 | 1 | ||
Result not available | 3.7 (1.2–11.9) | 0.025 | 4.2 (1.3–13.7) | 0.018 |
ICU management | N = 693 | |||
ICU resident at time of BSI | 1.5 (0.89–2.7) | 0.124 | 6.5 (3.7–11.6) | 0.0001 |
BSI requiring ICU management | 5.2 (3.3–8.4) | 0.0001 | 3.5 (1.8–6.7) | 0.0001 |
BSI not requiring ICU management | 1 | 1 | ||
Type of BSI | N = 693 | |||
CA | 1 | 1 | ||
HA | 1.2 (0.8–2) | 0.377 | 1 | |
HCA | 0.9 (0.4–1.9) | 0.806 | 1 | |
HIV infection | N = 693 | |||
Yes | 1.5 (0.8–2.9) | 0.221 | 1 | |
No | 1 | 1 | ||
Unknown status | 0.8 (0.5–1.5) | 0.523 | 1 |