Table 2 In vitro activity of 14 antimicrobial agents against 881 isolates of Streptococcus pneumoniae

Penicillin (oral)

0

0.016

0.032

.004–.064

0

1

1

.125–1

100

4

4

2–64-

–

Amoxicillin/clavulanic acid

0.3

0.016

0.032

.008–32

0

1

2

.008–2

60.7

8

16

.016–128

<  0.00001

Ceftriaxone (non meningitis)

0

0.016

0.064

.016–1

0.9

0.5

1

.016–4

40.7

2

8

.25–512

–

Cefuroxime oral

0.6

0.032

0.125

.016–8

45.4

2

4

.016–32

97.8

16

32

.008–512

< 0.00001

Cefaclor

2.2

1

2

.016–32

88.9

128

256

1–512-

99.8

>256

>256

2–512-

< 0.00001

Vancomycin

0

0.25

0.25

.008–.5

0

0.25

0.5

.064–.5

0

0.25

0.25

.064–1

–

Erythromycin

89

16

>256

.016–512

96.3

32

>256

.032–512

99.3

>256

>256

.032–512

< 0.00001

Azithromycin

94.6

32

>256

.016–512

94.4

32

>256

.032–512

99.3

>256

>256

.032–512

0.135

Clarithromycin

88.3

32

>256

.016–512

80.6

32

>256

.016–512

98.6

>256

>256

.032–512

0.063

Tetracycline

84.6

32

64

.064–128

92.6

16

64

.25–64

97.1

32

64

.25–128

< 0.00001

Levofloxacin

1.3

1

1

.025–32

5.6

1

1

.25–32

2

1

1

.5–64

0.163

Moxifloxacin

0.6

0.125

0.25

.016–16

1.9

0.125

0.25

.016–8

0.7

0.125

0.25

.016–16

0.666

Trimethoprim/sulfamethoxazole

34.9

0.5

8

.032–64

60.2

4

8

.064–32

89.5

8

16

.125–128

< 0.00001

Clindamycin

74.2

128

256

.016–512

88

128

256

.016–256

97.8

256

256

.016–512

< 0.00001