Comparison of line probe assay to BACTEC MGIT 960 system for susceptibility testing of first and second-line anti-tuberculosis drugs in a referral laboratory in South Africa

Table 2 Mutation pattern of gyrA, gyrB, rrs, eis, rpoB, katG, inhA and embB genes

Drug	Locus	Mutation	Frequency (no. of isolates)
OFX	gyrA	A90V	9
		S91P	1
		D94G	3
		D94A	1
		WT	2
	gyrB	–	–
KAN	rrs	A1401G	3
	rrs	C1402T	2
	eis	–	–
RIF	rpoB	S531 L	46
		D516V	27
		H526Y	7
		H526D	3
INH	katG	S315 T1	32
	katG	T8A	8
	inhA	C15T	14
EMB	embB	M306 V	15
EMB	embB	M306I	9

OFL ofloxacin, KAN kanamycin, RIF rifampicin, INH isoniazid, EMB ethambutol

ISSN: 1471-2334