Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia

Table 1 Final multivariable logistic regression model of risk factors for treatment failure at 30 days in patients with SAB

Variable	Univariate analysis	Multivariable logistic regression
Variable	p-value	Odds ratio	95% CI	p-value
Age > 70 years	<0.001	4.13	1.54-11.07	0.005
Albumin (g/L)	<0.001	0.88	0.80-0.96	0.003
CRP > 250 mg/L	0.002	5.41	1.93-15.19	0.001
Persistent fevers	0.029	6.65	1.73-25.62	0.006
Healthcare attendance	0.003	0.13	0.03-0.59	0.008
Pitt bacteraemia score ≥ 2^a	0.04	2.94	1.03-8.39	0.044
Echocardiogram performed	0.092	0.23	0.06-0.94	0.041
Appropriate empiric treatment	0.018	0.14	0.02-0.85	0.032
DNR order^b	<0.001			-
WCC (x 10⁹/L)	0.048			-
ICU admission	0.003			-
APACHE II score > 11.5^b	0.003			-
Combination treatment > 7 days	0.026			-
Severe sepsis	0.029			-
Body mass index (kg/m²)	0.037			-
Directed vancomycin treatment	0.044			-
Dementia	0.055			-
Directed flucloxacillin treatment	0.058			-
Nephrotoxicity	0.068			-
ARF at onset of SAB	0.07			-
Residence in LTCF^b	0.09			-
Female sex	0.091			-
MRSA	0.098			-

^aScore derived by CART analysis was > 1.5; as calculation of the score requires whole numbers, this is assumed to signify a Pitt bacteraemia score of ≥ 2
^bRemoved from multivariable model due to collinearity
CRP C-reactive protein, DNR do not resuscitate order, WCC white cell count, ICU intensive care unit, ARF acute renal failure, SAB staphylococcus aureus bacteraemia, LTCF long-term care facility, MRSA methicillin-resistant S. aureus, CART classification and regression tree, CI confidence interval

ISSN: 1471-2334