Table 5 Pharmacokinetic parameters of streptomycin in the hypoxia and control groups
From: Continuous hypoxia reduces the concentration of streptomycin in the blood
Pharmacokinetic parameters | Hypoxia | Control |
|---|---|---|
t1/2 | 67.618 h | 69.828 h |
AUC (0-t) | 30,562.744 mg/L.h | 39,512.611 mg/L.h |
AUC (0-∞) | 30,562.852 mg/L.h | 39,512.611 mg/L.h |
Ka | 5.078/h | 0.129/h |
Tmax | 20 h | 20 h |
Vz/F | 0.234 L/kg | 0.093 L/kg |
CLz/F | 0 L/h/kg | 0 L/h/kg |
Cmax | 177.51 mg/L | 310.3 mg/L |