DNA clearance rate (days) | Genome equivalent viable Mtb at day 7 a (95% CI) | Genome equivalent dead Mtb at day 7 b (95% CI) | Reduction in viable Mtb by day 7 | Change point in daysc (95% CI) | Early rate of killing d(log10/day) | Late rate of killing e(log10/day) | % decrease in rate of killing f | p-val for difference in rates | |
---|---|---|---|---|---|---|---|---|---|
log10 | % | ||||||||
0 | 4.4 (3.6, 5.2) | 0 | −1.6 (− 2.3, − 0.9) | 97.2% (85.8, 99.5) | 8.8 (3.3, 14.2) | −0.22 (− 0.32, − 0.12) | −0.07 (− 0.09, − 0.05) | 69.4% | 0.004 |
0.5 | 4.1 (3.2, 4.9) | 3.9 (2.2, 5.6) | − 1.9 (− 2.7, − 1.0) | 98.6% (90.2, 99.8) | 7 (2.7, 11.3) | −0.26 (− 0.38, − 0.14) | −0.07 (− 0.09, − 0.05) | 74.2% | 0.002 |
0.75 | 4.02 (3.2, 4.8) | 4.1 (3.2, 4.9) | −1.9 (− 2.6, − 1.3) | 98.7% (94.3, 99.7) | 6.5 (3.4, 9.6) | − 0.29 (− 0.42, − 0.15) | −0.07 (− 0.08, − 0.05) | 76.8% | 0.003 |
1 | 4.0 (3.1, 4.8) | 4.2 (3.4, 5.0) | −1.9 (− 2.6, − 1.3) | 98.8% (94.6, 99.7) | 5.7 (1.9, 9.6) | − 0.32 (− 0.53, − 0.12) | −0.07 (− 0.08, − 0.05) | 79.6% | 0.02 |
1.25 | 3.9 (3.1, 4.7) | 4.4 (3.6, 5.1) | − 1.9 (− 2.6, − 1.3) | 98.8% (94.7, 99.7) | 5.0 (0.5, 9.5) | − 0.36 (− 0.67, − 0.05) | −0.06 (− 0.08, − 0.05) | 82.2% | 0.06 |