Case | Reference | Age/gender | Geographical area | Clinical presentation | Initial diagnosis | Associated factors | Diagnosis method | Fungal culture | Aspergillus species involved | treatment | Follow up period and Outcome |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | Rao PB. 1969 | 48/M | Pondicherry, S. India | Hoarseness of voice | NA | None | HE | No | NA | No treatment | 2Â M-asymptomati |
2 | Ferlito A. et al. 1974 | 76/M | Verona, Italy | Hoarseness of voice | NA | None | HE | No | NA | No treatment | 2Â M- asymptomatic |
3 | Kheir SM et al. 1983 | 50/M | Birmingham, UK | Hoarseness of voice | Malignancy | COPD | HE and Immunofluorescence studies | No | NA | Topical nystatin powder | 24Â M- asymptomatic |
4 | Benson-Mitchell R et al. 1994 | 62/M | London, UK | Hoarseness of voice | Malignancy | None | HE | No | NA | No treatment | 2Â M- asymptomatic |
5 | Nong D, et al. 1997 | 30–40 4 M + 4F | China | Hoarseness of voice leading to aphonia, sore throat, | Acute laryn giti, TB, malignancy | None | NA | NA | NA | NA | NA |
6 | Beust L, et al.. 1998 | 53/M | Rennes, France | Hoarseness of voice, respiratory distress | None | None | HE | No | NA | Laryngectomy | 3Â M- asymptomatic |
7 | Fairfax AJ, et al. 1999 | 75/M | Staffor, UK | Hoarseness of voice, aphonia | None | None | HE and culture | Yes | A. fumigatus | AMP-lozenges, 10 mg-4 W | 1 M- Improved |
8 | Dean CM, et al. 2001 | 17/F | Philadelphia, USA. | Hoarseness of voice, vocal fatigue | None | NG | NA | NA | NA | NA | NA |
9 | Ogawa Y, et al. 2002 | 73/M | Tokyo, Japan | Hoarseness of voice (History of Radiotherapy and DB) | Malignancy | None | HE, surgery | NO | NA | Oral ITCZ- 8Â W and AMP-B gargle | 2Â M- No recurrence |
10 | Wittkopf J, et al. 2006 | 62/F | Iowa, USA | Fluctuating hoarseness | True vocal fold cyst (? aspergilloma) | Type II DB (well-controlled), hypertension, and GERD | HE | No | NA | Surgery | NA- No recurrence |
11 | Ran Y, et al. 2008 | 36/F | China | Hoarseness of voice, vocal fatigue | None | Dexamethasone therapy for rhinitis and asthma | HE, KOH, SEM and Culture | Yes | a A fumigatus | Oral ITCZ (200Â mg bd-4Â W) | 1Â M- asymptomatic |
12 | Liu YC, et al. 2010 | 30/F 32/F | Hangzhou, China | Hoarseness of voice | True vocal cord cyst | Vocal abuse, broad spectrum antibiotic therapy | HE and Culture and FFPE-PCR | Yes (no growth) | a A. fumigatus | Oral ITCZ (200Â mg bd- 4Â W) | 1Â M- asymptomatic |
13 | Ran Y, et al. 2011 | 30/F | Chengdu, China | Hoarseness of voice, vocal fatigue, expectoration, and occasional vomiting | Laryngitis | Vocal abuse, oral Antibiotics and dexamethasone use | HE, KOH, SEM and Culture | Yes | a A fumigatus | Oral ITCZ (200Â mg bd- first 2Â W, 200Â mg qd next 2Â W | 1Â M- asymptomatic |
14 | Sundarray C et al. 2011 | NA | Cuttack, India | NA | NA | NA | NA | NA | NA | NA | NA |
15 | Ran Y, et al. 2013 | 23/F | China | Hoarseness of voice, severe paroxysmal cough, tachypnea | None | Oral sex | HE, SEM and Culture | Yes | a A. fumigatus | Oral ITCZ (200Â mg bd- 4Â W | 1Â M- asymptomatic |
16 | Doloi PK, et al. 2014 | 35/F | Assam, India | Hoarseness of voice, cough | None | Keratosis of the larynx | HE, KOH and Culture | Yes | A. fumigatus | Oral ITCZ (100Â mg qd- 3Â W) | 3Â W- asymptomatic |
17 | Al-Ogaili Z, et al. 2014 | 77/F | Australia | Dysphagia and hoarseness | Lymphoma | Smoking,inhaled corticosteroids | HE and Culture | Yes | Not speciated | NA | NA |
18 | Gangopadhyay M, et al. 2014 | 42/M | West Bengal, India. | Hoarsenes, fever, cough with expectoration | Malignancy | Smoking, vocal abuse | HE, and Culture | Yes | A. niger | Oral ITCZ | 18Â M- asymptomatic |
19 | Ravikumar et al. 2014 | 34/F 52/F 38/M | Tamil Nadu, India | Hoarseness, cough, Dysphagia, vocal fatigue | None | NA GERD | HE and KOH mount | No | NA | Oral ITCZ (100Â mg bd- 3Â W) | 3Â W- asymptomatic |
20 | David et al. 2014 | 59/F | Sydney, Australia | Hoarseness of voice | None | Asthma- fluticasone therapy | HE | No | NA | Oral ITCZ | NA: No recurrence |
21 | M Dutta, et al. 2015 | 45/F | WB, India | Hoarseness of voice | Malignancy | None | HE, KOH and Culture | Yes | A. fumigatus | Oral ITCZ (300Â mg qd-3Â W) | 6Â M- asymptomatic |
22 | JCR Villanueva, et al. 2015 | 28/F | Philippines | Hoarseness of voice | Antibiotics and steroids | None | HE | No | No | Oral VCZ (400 mg qd– 4 W) | 1 M- asymptomatic |
23 | Arpita Saha, et al. 2015 | 28/F | Odisha, India | severe dysphonia | None | Asthma, long-term steroid inhaler, vocal abuse, broadspectrum antibiotics | HE, and Culture | Yes | A. fumigatus | VCZ (200Â mg bd-8Â days) | 2Â W- asymptomatic |
24 | Santosh Kumar Swain et al. 2016 | 35/M | Orissa, India | Hoarseness of voice | Flute player | Malignancy | HE, KOH and Culture | Yes | A. fumigatus | Oral ITCZ- 100Â mg bd- 3Â W | 6Â M- asymptomatic |
25 | Richard H. et al.. 2016 | 73/F | USA | persistent hoarseness | None | Inhaled and oral corticosteroids, and nebulized tobramycin | HE | NO | NA | Oral ITCZ-20Â W | 5Â M- asymptomatic |
26 | Santosh Kumar et al. 2017 | 12/M | India | Hoarseness of voice | None | Asthma, inhaled corticosteroids, microlaryngeal surgery with stripping of the vocal cords | HE, and Culture | Yes | A. fumigatus | Oral ITCZ-50Â mg bd- 3Â W | 3Â W- asymptomatic |
27 | Soumen Chatterjee et.al. 2017 | 43/F | India West Bengal | Hoarseness of voice | None | None | HE, KOH and Culture | Yes | A. fumigatus | Oral ITC -100Â mg bd- 8Â W | 1Â M- asymptomatic |
28 | Present study | 22/M | Nepal | hoarseness and frequent expectoration | None | None | HE, KOH, Culture and FFPET-PCR assay | Yes | a A. fumigatus | Oral ITCZ- 4Â W | 1Â M- asymptomatic No recurrence |