AIDS-related opportunistic illnesses and early initiation of HIV care remain critical in the contemporary HAART era: a retrospective cohort study in Taiwan

Table 2 Univariable and multivariable analysis for factors predicting AOIs within 90 days of initial HIV care

	Univariable analysis		Multivariable analysis^a
	OR (95% CI)	P	AOR (95% CI)	P
Age, per 10-year increase	2.35 (2.02–2.74)	< 0.001	1.95 (1.58–2.41)	< 0.001
Male sex	0.66 (0.26–1.71)	0.39	2.38 (0.62–9.16)	0.21
HIV transmission route
Homosexual	1.00 (Reference)		1.00 (Reference)
Heterosexual	3.61 (2.48–5.26)	< 0.001	1.83 (1.05–3.19)	0.034
Bisexual	2.55 (1.51–4.31)	< 0.001	1.95 (0.96–3.94)	0.065
IDU	3.99 (1.37–11.66)	0.011	1.57 (0.35–6.96)	0.56
Unknown	7.10 (1.57–32.02)	0.011	1.39 (0.21–9.17)	0.73
Period
Period 1 (2010–2011)	1.00 (Reference)		1.00 (Reference)
Period 2 (2012–2013)	0.87 (0.63–1.21)	0.41	0.87 (0.56–1.34)	0.52
Period 3 (2014–2015)	0.80 (0.56–1.13)	0.20	0.92 (0.58–1.46)	0.72
Chronic kidney disease	4.03 (0.81–20.1)	0.089	0.84 (0.77–9.17)	0.89
Diabetes mellitus	3.78 (1.65–8.68)	0.002	1.02 (0.29–3.57)	0.97
Subgroup of CD4 cell count at presentation
CD4 count ≥500 cells/μL	1.00 (Reference)		1.00 (Reference)
CD4 count 200–499 cells/μL	1.05 (0.29–3.78)	0.94	0.91 (0.25–3.33)	0.88
CD4 count < 200 cells/μL	49.54 (15.60–157.40)	< 0.001	40.84 (12.59–132.49)	< 0.001
HBsAg seropositivity	2.09 (1.38–3.16)	0.001	1.32 (0.76–2.29)	0.33
HCV seropositivity	2.30 (1.20–4.39)	0.012	2.07 (0.81–5.34)	0.13

Abbreviations: AIDS acquired immune deficiency syndrome, AOI AIDS-defining opportunistic illness, AOR adjusted odd ratio, CI confidence interval, HBsAg hepatitis B surface antigen, HCV hepatitis C virus, OR odd ratio, IDU intravenous drug users
^aAll variables in the univariate analysis were selected for subsequent multivariate analysis

ISSN: 1471-2334