Table 4 Univariable and multivariable analyses of factors associated with mortality for patients who were not on ART at start of TB treatment
From: HIV and TB co-infection in the ART era: CD4 count distributions and TB case fatality in Cape Town
PYRS | Deaths | Univariable | Multivariable | |||
|---|---|---|---|---|---|---|
Characteristic | HR (95% CI) | P-value | aHR (95% CI) | P-value | ||
Calendar year | ||||||
2009 | 5169 | 823 | 1 | 0.03 | 1 | 0.38 |
2010 | 5163 | 733 | 0.89 (0.81–0.98) | < 0.001 | 1.05 (0.94–1.18) | 0.66 |
2011 | 4769 | 616 | 0.81 (0.73–0.90) | < 0.001 | 1.03 (0.91–1.16) | 0.09 |
2012 | 3943 | 512 | 0.82 (0.73–0.91) | < 0.001 | 1.12 (0.98–1.27) | 0.55 |
2013 | 3361 | 401 | 0.73 (0.65–0.83) | 1.04 (0.91–1.21) | ||
Age (per 10 years increase) | 22,405 | 3085 | 1.34 (1.30–1.39) | < 0.001 | 1.38 (1.32–1.44) | < 0.001 |
Female gender | 11,662 | 1528 | 1 | 0.004 | 1 | 0.004 |
Male gender | 10,743 | 1557 | 1.11 (1.03–1.19) | 0.89 (0.82–0.96) | ||
Re-treatment TB | 7142 | 1122 | 1 | 1 | ||
New TB | 15,263 | 1963 | 0.76 (0.71–0.82) | < 0.001 | 0.67 (0.62–0.73) | < 0.001 |
PTB | 18,083 | 2391 | 1 | 1 | ||
EPTB | 4321 | 694 | 1.20 (1.11–1.31) | < 0.001 | 1.25 (1.14–1.38) | < 0.001 |
CD4 (per increase of 50 cells/mm3) | 21,574 | 2807 | 0.85 (0.84–0.86) | < 0.001 | 0.82 (0.81–0.83) | < 0.001 |
Did not start ART | 7037 | 1254 | 1 | 1 | ||
Started ART | 13,145 | 1301 | 0.56 (0.52–0.61) | < 0.001 | 0.39 (0.35–0.42) | < 0.001 |